Cadmium removal out of human plasma using ion-imprinted beads in a magnetic column

被引：63

作者：

Candan, Nilgun ^{[2
]}

Tuzmen, Nalan ^{[2
]}

Andac, Muge ^{[1
]}

Andac, Cenk A. ^{[3
]}

Say, Ridvan ^{[4
]}

Denizli, Adil ^{[1
]}

机构：

[1] Hacettepe Univ, Div Biochem, Dept Chem, Ankara, Turkey

[2] Dokuzeylul Univ, Dept Chem, Izmir, Turkey

[3] Dicle Univ, Dept Chem, Diyarbakir, Turkey

[4] Anadolu Univ, Dept Chem, Eskisehir, Turkey

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2009年 / 29卷 / 01期

关键词：

Ion imprinting; Magnetic beads; Molecular recognition; Cadmium removal; Metal detoxification; Affinity binding; ANTIBODY REMOVAL; RECOGNITION; PROTEIN; ADSORPTION; POLYMERS;

D O I：

10.1016/j.msec.2008.06.002

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The aim of this study is to utilize ion-imprinted magnetic beads in the selective removal of Cd2+ ions out of human plasma overdosed with Cd2+ ions. The Cd (2+) imprinted magnetic poly(HEMA-MAC) (mPHEMAC-Cd2+) beads were produced by suspension polymerization in the presence of magnetite Fe3O4 in a nano-powder form. The template Cd2+ ions could be reversibly detached from the matrix to form mPHEMAC-Cd2+ beads using 0.1 M thiourea solution. The specific surface area of the mPHEMAC-Cd2+ beads was found to be 24.7 m(2)/g. The MAC and Fe3O4 contents of the mPHEMAC-Cd2+ beads were found to be 41.8 mu mol/g polymer and 8.2% on the average. The Cd2+ adsorption capacity of mPHEMAC-Cd2+ columns decreased drastically from 48.8 mu mol/g to 20.0 mu mol/g as the flow rate is increased from 0.50 ml/min to 3.0 ml/min. The maximum adsorption capacity of the mPHEMAC-Cd2+ beads was determined to be 48.8 mu mol Cd2+/g on the average. The relative selectivity coefficients of the mPHEMAC beads for Cd2+/Pb2+ and Cd2+/Zn2+ were 22.6 and 160.7 times greater than those of the non-imprinted magnetic PHEMAC (mPHEMAC) beads, respectively. The mPHEMAC-Cd2+ beads are reusable for many times with no significant decrease in their adsorption capacities. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：144 / 152

页数：9

共 36 条

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