Fondaparinux in heparin-induced thrombocytopenia

被引：3

作者：

Gevaert, Andreas ^{[1
]}

Smets, Hilde ^{[2
]}

Vercauteren, Roeland ^{[3
]}

机构：

[1] Univ Antwerp, Dept Internal Med, Antwerp, Belgium

[2] GZA St Augustinus Hosp, Dept Nephrol, B-2610 Antwerp, Belgium

[3] GZA St Augustinus Hosp, Dept Cardiol, B-2610 Antwerp, Belgium

来源：

ACTA CARDIOLOGICA | 2013年 / 68卷 / 05期

关键词：

Heparin-induced thrombocytopenia; thrombosis; pulmonary embolism; fondaparinux;

D O I：

10.1080/AC.68.5.2994477

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin-induced thrombocytopenia is a potentially life-threatening complication of heparin or low-molecular-weight heparin administration. We describe the case of a patient with heparin-induced thrombocytopenia complicated by pulmonary embolism, successfully treated with fondaparinux, a factor Xa inhibitor. We also review the literature regarding the use of this anticoagulant in heparin-induced thrombocytopenia complicated by thrombosis. Few treatment options are available in Belgium, and there is little evidence regarding newer anticoagulants.

引用

页码：517 / 520

页数：4

共 5 条

[1] Heparin-induced thrombocytopenia
Arepally, Gowthami M.
Ortel, Thomas L.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (08) : 809 - 817
[2] Prospective evaluation of PF4/heparin immunoassays for the diagnosis of heparin-induced thrombocytopenia
Bakchoul, T.
Giptner, A.
Najaoui, A.
Bein, G.
Santoso, S.
Sachs, U. J. H.
[J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (08) : 1260 - 1265
[3] The management of heparin-induced thrombocytopenia
Keeling, D
Davidson, S
Watson, H
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2006, 133 (03) : 259 - 269
[4] Treatment and Prevention of Heparin-Induced Thrombocytopenia Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Linkins, Lori-Ann
Dans, Antonio L.
Moores, Lisa K.
Bona, Robert
Davidson, Bruce L.
Schulman, Sam
Crowther, Mark
[J]. CHEST, 2012, 141 (02) : E495S - E530S
[5] The serological profile of fondaparinux-associated heparin-induced thrombocytopenia syndrome
Warkentin, Theodore E.
Chakraborty, Anup K.
Sheppard, Jo-Ann I.
Griffin, Danielle K.
[J]. THROMBOSIS AND HAEMOSTASIS, 2012, 108 (02) : 394 - 396

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