Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future

被引:54
作者
Kennedy, Joshua L. [1 ,2 ,3 ]
Stoner, Ashley N. [1 ]
Borish, Larry [4 ,5 ,6 ]
机构
[1] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Dept Internal Med, Little Rock, AR 72205 USA
[3] Univ Arkansas Med Sci, Arkansas Childrens Res Inst, Little Rock, AR 72205 USA
[4] Univ Virginia Hlth Syst, Dept Med, Charlottesville, VA USA
[5] Univ Virginia Hlth Syst, Dept Microbiol, Charlottesville, VA USA
[6] Univ Virginia Hlth Syst, Carter Immunol Ctr, Charlottesville, VA USA
基金
美国国家卫生研究院;
关键词
5-LIPOXYGENASE INHIBITOR ZILEUTON; INNATE LYMPHOID-CELLS; EXHALED NITRIC-OXIDE; LONG-TERM TREATMENT; ASTHMATIC-PATIENTS; CHRONIC RHINOSINUSITIS; NASAL POLYPS; AIRWAY INFLAMMATION; NATURAL-HISTORY; LEUKOTRIENE;
D O I
10.2500/ajra.2016.30.4370
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Aspirin-exacerbated respiratory disease (AERD) is a late onset condition characterized by the Samter triad (aspirin sensitivity [as well as sensitivity to any nonselective cyclooxygenase inhibitor], nasal polyps, asthma) and additional features, including eosinophilic chronic rhinosinusitis, hypereosinophilia, anosmia, frequent absence of atopy, and, intolerance to ingestion of red wine and other alcoholic beverages. The diagnosis is rare, and, because of this, it is also often missed by physicians. However, it is highly overexpressed in patients with severe asthma (and severe chronic rhinosinusitis with nasal polyps), which makes its recognition essential. For this review, we considered mechanisms involved in the pathogenesis of this disease and discussed the clinical symptoms of AERD. We also discussed the role of aspirin desensitization in the treatment of AERD. Also, we considered medications (e. g, leukotriene modifiers) and surgical interventions that have a role in the treatment of AERD.
引用
收藏
页码:407 / 413
页数:7
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