Tumor microenvironment: Sanctuary of the devil

被引：651

作者：

Hui, Lanlan ^{[1
]}

Chen, Ye ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Inst Genet, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2015年 / 368卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Tumor microenvironment; Drug resistance; Combination therapy; STEM-CELL NICHE; IN-VIVO MODEL; BONE-MARROW; THERAPY RESISTANCE; CANCER METASTASIS; DRUG-RESISTANCE; DOWN-REGULATION; IMMUNE CELLS; T-CELLS; MACROPHAGES;

D O I：

10.1016/j.canlet.2015.07.039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor cells constantly interact with the surrounding microenvironment. Increasing evidence indicates that targeting the tumor microenvironment could complement traditional treatment and improve therapeutic outcomes for these malignancies. In this paper, we review new insights into the tumor microenvironment, and summarize selected examples of the cross-talk between tumor cells and their microenvironment, which have enhanced our understanding of pathophysiology of the microenvironment. We believe that this rapidly moving field promises many more to come, and they will guide the rational design of combinational therapies for success in cancer eradication. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：7 / 13

页数：7

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