Cancer stem cells as 'units of selection'

被引：61
作者：
Greaves, Mel [1 ]
机构：
[1] Inst Canc Res, Haematooncol Res Unit, Div Mol Pathol, Sutton SM2 5NG, Surrey, England
来源：
EVOLUTIONARY APPLICATIONS | 2013年 / 6卷 / 01期
关键词：
disease Biology; evolutionary Medicine; natural selection and contemporary evolution; ACQUIRED-RESISTANCE; CLONAL EVOLUTION; MYELOID-LEUKEMIA; MUTATION; DISEASE; GROWTH; HETEROGENEITY; DIAGNOSIS; IMATINIB; HISTORY;
D O I：
10.1111/eva.12017
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cancer development is widely recognized to be a somatic cell evolutionary process with complex dynamics and highly variable time frames. Variant cells and descendent subclones gain competitive advantage via their fitness in relation to micro-environmental selective pressures. In this context, the unit of selection is the cell, but not any cell. The so-called cancer stem cells have the essential properties required to function as the key units of selection, particularly with respect to their proliferative potential and longevity. These cells drive evolutionary progression of disease and provide reservoirs for relapse or recurrence and drug resistance. They represent the prime, but elusive and moving, targets for therapeutic control.
引用
收藏
页码：102 / 108
页数：7
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