Small Organoselenium Compounds: More than just Glutathione Peroxidase Mimics

被引：133

作者：

Wirth, Thomas ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, S Glam, Wales

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 35期

关键词：

antioxidants; ebselen; glutathione peroxidase; reactive oxygen species; selenium; PZ-51;

D O I：

10.1002/anie.201505056

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Se-ing and doing: Isoselenazoles are novel, very potent antioxidant derivatives offering remarkable cytoprotection to human cells. Synthetically available in only a few steps, these compounds have the potential to fight diseases caused by oxidative stress. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：10074 / 10076

页数：3

相关论文

共 17 条

[1] Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation [J].

Bartolini, D. ;

Piroddi, M. ;

Tidei, C. ;

Giovagnoli, S. ;

Pietrella, D. ;

Manevich, Y. ;

Tew, K. D. ;

Giustarini, D. ;

Rossi, R. ;

Townsend, D. M. ;

Santi, C. ;

Galli, F. .

FREE RADICAL BIOLOGY AND MEDICINE, 2015, 78 :56-65

[2] Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants [J].

Bhabak, Krishna P. ;

Mugesh, Govindasamy .

ACCOUNTS OF CHEMICAL RESEARCH, 2010, 43 (11) :1408-1419

[3]

Bhowmick D., 2015, ANGEW CHEM, V127, P8569

[4] Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage [J].

Bhowmick, Debasish ;

Srivastava, Shubhi ;

D'Silva, Patrick ;

Mugesh, Govindasamy .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (29) :8449-8453

[5]

Bhuyan BJ, 2013, HANDBOOK OF CHALCOGEN CHEMISTRY: NEW PERSPECTIVES IN SULFUR, SELENIUM AND TELLURIUM, 2ND EDITION, VOL 2, P25

[6] THE REFINED STRUCTURE OF THE SELENOENZYME GLUTATHIONE-PEROXIDASE AT 0.2-NM RESOLUTION [J].

EPP, O ;

LADENSTEIN, R ;

WENDEL, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 133 (01) :51-69

[7] GLUTATHIONE PEROXIDASE - SELENOENZYME [J].

FLOHE, L ;

GUNZLER, WA ;

SCHOCK, HH .

FEBS LETTERS, 1973, 32 (01) :132-134

[8] A NOVEL BIOLOGICALLY-ACTIVE ORGANOSELENIUM COMPOUND .1. GLUTATHIONE PEROXIDASE-LIKE ACTIVITY INVITRO AND ANTIOXIDANT CAPACITY OF PZ-51 (EBSELEN) [J].

MULLER, A ;

CADENAS, E ;

GRAF, P ;

SIES, H .

BIOCHEMICAL PHARMACOLOGY, 1984, 33 (20) :3235-3239

[9] Synthesis and biological evaluation of new nitrogen-containing diselenides [J].

Nascimento, Vanessa ;

Ferreira, Natasha L. ;

Canto, Romulo F. S. ;

Schott, Karen L. ;

Waczuk, Emily P. ;

Sancineto, Luca ;

Santi, Claudio ;

Rocha, Joao B. T. ;

Braga, Antonio L. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 87 :131-139

[10]

Paoletti R., 1994, OXIDATIVE PROCESSES