Hypothermic Circulatory Arrest Using Antegrade Cerebral Perfusion Is Safe for Elective Aortic Arch Surgery

被引:3
作者
Matt, Peter [1 ]
Albrecht, Franziska [1 ]
Rueter, Florian [1 ]
Grapow, Martin [1 ]
Pargger, Hans [2 ]
Fassl, Jens [2 ]
Reuthebuch, Oliver [1 ]
Eckstein, Friedrich [1 ]
机构
[1] Univ Basel Hosp, Div Cardiac Surg, CH-4031 Basel, Switzerland
[2] Univ Basel Hosp, Dept Anesthesia & Intens Care Med, CH-4031 Basel, Switzerland
关键词
aneurysm; aorta; aortic; outcomes; REPLACEMENT; PROTECTION; RETROGRADE;
D O I
10.1055/s-0032-1331466
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background We hypothesized that hypothermic circulatory arrest (HCA) can be performed with a low operative risk and does not add to the morbidity in elective procedures. Methods A total of 178 patients with a mean ( SD) age of 62 ( 10) years underwent HCA for elective aortic surgery from April 2008 to September 2011. Pre- and postoperative clinical data were collected prospectively. Results Hemiarch replacement was performed in 97% patients. Mean logistic Euroscore I was 17% (+/- 15). HCA was performed at 26 degrees C bilateral tympanic temperature. Mean HCA duration was 17 (+/-) min. Mean cross-clamp time was 106 (+/- 39) min. Overall 30-day mortality was 2% and stroke occurred in 4% of patients. Overall 6-month survival was 96%. Cox regression analysis for 6-month survival revealed four variables with significant influence: the logistic Euroscore I (p = 0.008), age (p = 0.04), cross-clamp time (p = 0.008), and reoperation for bleeding complications (p = 0.04). Conclusions HCA with open distal anastomosis for elective aortic repair can be performed with low operative mortality, even in the elderly, and seems not to add to the morbidity of the procedure.
引用
收藏
页码:553 / 558
页数:6
相关论文
共 15 条
[1]   Mortality and Neurologic Injury After Surgical Repair With Hypothermic Circulatory Arrest in Acute and Chronic Proximal Thoracic Aortic Pathology Effect of Age on Outcome [J].
Czerny, Martin ;
Kraehenbuehl, Eva ;
Reineke, David ;
Sodeck, Gottfried ;
Englberger, Lars ;
Weber, Alberto ;
Schmidli, Juerg ;
Kadner, Alexander ;
Erdoes, Gabor ;
Schoenhoff, Florian ;
Jenni, Hansjoerg ;
Stalder, Mario ;
Carrel, Thierry .
CIRCULATION, 2011, 124 (13) :1407-1413
[2]   Straight deep hypothermic arrest: Experience in 394 patients supports its effectiveness as a sole means of brain preservation [J].
Gega, Arjet ;
Rizzo, John A. ;
Johnson, Michele H. ;
Tranquilli, Maryann ;
Farkas, Emily A. ;
Elefteriades, John A. .
ANNALS OF THORACIC SURGERY, 2007, 84 (03) :759-767
[3]  
Gill Michael, 2009, Interact Cardiovasc Thorac Surg, V9, P693, DOI 10.1510/icvts.2009.213405
[4]   Cerebral protection during aortic arch surgery [J].
Griepp, RB .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2001, 121 (03) :425-427
[5]  
GRIEPP RB, 1975, J THORAC CARDIOV SUR, V70, P1051
[6]   2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease [J].
Hiratzka, Loren F. ;
Bakris, George L. ;
Beckman, Joshua A. ;
Bersin, Robert M. ;
Carr, Vincent F. ;
Casey, Donald E., Jr. ;
Eagle, Kim A. ;
Hermann, Luke K. ;
Isselbacher, Eric M. ;
Kazerooni, Ella A. ;
Kouchoukos, Nicholas T. ;
Lytle, Bruce W. ;
Milewicz, Dianna M. ;
Reich, David L. ;
Sen, Souvik ;
Shinn, Julie A. ;
Svensson, Lars G. ;
Williams, David M. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (14) :E27-E129
[7]   Hypothermic circulatory arrest with selective antegrade cerebral perfusion in ascending aortic and aortic arch surgery: A risk factor analysis for adverse outcome in 501 patients [J].
Khaladj, Nawid ;
Shrestha, Malakh ;
Meck, Sara ;
Peterss, Sven ;
Kamiya, Hiroyuki ;
Kallenbach, Klaus ;
Winterhalter, Michael ;
Hoy, Ludwig ;
Haverich, Axel ;
Hagl, Christian .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2008, 135 (04) :908-914
[8]   Lessons on the pathogenesis of aneurysm from heritable conditions [J].
Lindsay, Mark E. ;
Dietz, Harry C. .
NATURE, 2011, 473 (7347) :308-316
[9]   Retrograde and Antegrade Cerebral Perfusion: Results in Short Elective Arch Reconstructive Times [J].
Milewski, Rita Karianna ;
Pacini, Davide ;
Moser, G. William ;
Moeller, Patrick ;
Cowie, Doreen ;
Szeto, Wilson Y. ;
Woo, Y. Joseph ;
Desai, Nimesh ;
Di Marco, Luca ;
Pochettino, Alberto ;
Di Bartolomeo, Roberto ;
Bavaria, Joseph E. .
ANNALS OF THORACIC SURGERY, 2010, 89 (05) :1448-1457
[10]   Prospective comparative study of brain protection in total aortic arch replacement: Deep hypothermic circulatory arrest with retrograde cerebral perfusion or selective antegrade cerebral perfusion [J].
Okita, Y ;
Minatoya, K ;
Tagusari, O ;
Ando, M ;
Nagatsuka, K ;
Kitamura, S .
ANNALS OF THORACIC SURGERY, 2001, 72 (01) :72-79