A summary on non-viral systems for gene delivery based on natural and synthetic polymers

被引：36

作者：

Sarvari, Raana ^{[1
,2
]}

Nouri, Mohammad ^{[3
]}

Agbolaghi, Samira ^{[4
]}

Roshangar, Laila ^{[1
]}

Sadrhaghighi, Amirhouman ^{[5
]}

Seifalian, Alexander M. ^{[6
]}

Keyhanvar, Peyman ^{[1
,7
,8
,9
]}

机构：

[1] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Stem Cell & Regenerat Med Inst, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Reprod Biol, Tabriz, Iran

[4] Azarbaijan Shahid Madani Univ, Fac Engn, Chem Engn Dept, Tabriz, Iran

[5] Tabriz Univ Med Sci, Fac Dent, Dept Orthodont, Tabriz, Iran

[6] London Innovat Bio Sci Ctr, Nanotechnol & Regenerat Med Commercializat Ctr Lt, London, England

[7] Tabriz Univ Med Sci, Sch Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran

[8] Univ Sci Educ & Res Network USERN, Convergence Knowledge Technol & Soc Network CKTS, Tabriz, Iran

[9] ARTAN110 Startup Accelerator, Tabriz, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2022年 / 71卷 / 04期

关键词：

Gene delivery; gene therapy; natural polymer; synthetic polymer; vector; HIGH TRANSFECTION EFFICIENCY; ENDOTHELIAL GROWTH-FACTOR; GLYCOL)-MODIFIED GELATIN NANOPARTICLES; SELF-ASSEMBLED NANOPARTICLES; IN-VITRO; SIRNA DELIVERY; PLASMID DNA; MESSENGER-RNA; REDV PEPTIDE; POLYAMIDOAMINE DENDRIMER;

D O I：

10.1080/00914037.2020.1825081

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Gene delivery systems necessitate the gene therapy, which is a unique approach for applying the tunable genes to treat any diseases. To tackle down the disadvantages of viral vectors like high cost, poor target cell specificity, and inability in transferring the large size genes, the non-viral vectors/carriers have been introduced for achieving better efficacy in gene therapy. A variety of carriers including liposomes, metallic/polymeric nanoparticles, dendrimers, gelatins, quantum dots/rods, etc. has been depicted distinct features in the gene therapy. Herein, the advances and applications of natural/synthetic polymeric carriers have been summarized in gene therapy and disadvantages/challenges have been also discussed.

引用

页码：246 / 265

页数：20