Treatment of EARLY-ONSET Gorham Syndrome with 8-Year Follow-Up

被引：2

作者：

Maruani, Annabel ^{[5
,6
]}

Thimon, Sylvie ^{[1
,5
]}

de Courtivron, Benoit ^{[2
,5
]}

de Pinieux, Gonzague ^{[3
,5
]}

Baulieu, Francoise ^{[4
,5
]}

Machet, Laurent ^{[1
,5
,6
]}

Lorette, Gerard ^{[1
,5
]}

机构：

[1] Univ Tours, Dept Dermatol, Tours, France

[2] Univ Tours, Dept Pediat Orthopaed Surg, Tours, France

[3] Univ Tours, Dept Pathol, Tours, France

[4] Univ Tours, Dept Nucl Med, Tours, France

[5] CHRU Tours, F-37044 Tours 9, France

[6] INSERM, U930, Tours, France

来源：

PEDIATRIC DERMATOLOGY | 2013年 / 30卷 / 03期

关键词：

MASSIVE OSTEOLYSIS; STOUT-DISEASE; RADIATION-THERAPY; RADIOTHERAPY;

D O I：

10.1111/j.1525-1470.2011.01712.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A case of Gorham disease with several years of follow-up is reported. At birth he had a mass in the thigh which was had pathology demonstrating a lymphangioma. By age 3 years, he had lymphedema of the ipsilateral foot and discrepant leg lengths. Radiography revealed heterogenous dystrophy of the bones and osteolysis of the hallux. At age 6, a spontaneous fracture of the right tibia was treated with surgery. Histopathology of a bone sample demonstrated bone remodelling, fibrous tissue, and large vascular lacunas within bone tissue, bordered by cells expressing the lymphaticmarker D240. At 8 years old, lymphedema of the right inferior leg had increased, leg lengths still differed, but other clinical signs were absent.

引用

页码：391 / 394

页数：4

共 23 条

[1] Cutaneous lymphatic malformations in disappearing bone (Gorham-Stout) disease: A novel clue to the pathogenesis of a rare syndrome [J].

Bruch-Gerharz, Daniela ;

Gerharz, Claus-Dieter ;

Stege, Helger ;

Krutmann, Jean ;

Pohl, Michael ;

Koester, Rainer ;

Ruzicka, Thomas .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2007, 56 (02) :S21-S25

[2] Gorham-Stout disease of costo-vertebral localization: Radiographic, scintigraphic, computed tomography, and magnetic resonance imaging findings [J].

Ceroni, D ;

De Coulon, G ;

Regusci, M ;

Kaelin, A .

ACTA RADIOLOGICA, 2004, 45 (04) :464-468

[3]

Chattopadhyay P, 2009, SINGAP MED J, V50, pE259

[4] Gorham-Stout syndrome: A monocyte-mediated cytokine propelled disease [J].

Colucci, S ;

Taraboletti, G ;

Primo, L ;

Viale, A ;

Roca, C ;

Valdembri, D ;

Geuna, M ;

Pagano, M ;

Grano, M ;

Pogrel, AM ;

Harris, AL ;

Athanasou, NN ;

Mantovani, A ;

Zallone, A ;

Bussolino, F .

JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 (02) :207-218

[5] Interleukin-6: A potential mediator of the massive osteolysis in patients with Gorham-Stout disease [J].

Devlin, RD ;

Bone, HG ;

Roodman, GD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (05) :1893-1897

[6] A Case of Gorham's Disease with Chylothorax Treated Curatively with Radiation Therapy [J].

Duffy, Bethany M. ;

Manon, Rafael ;

Patel, Rakesh R. ;

Welsh, James S. .

CLINICAL MEDICINE & RESEARCH, 2005, 3 (02) :83-86

[7] GORHAM MASSIVE OSTEOLYSIS - THE ROLE OF RADIATION-THERAPY AND A REVIEW OF THE LITERATURE [J].

DUNBAR, SF ;

ROSENBERG, A ;

MANKIN, H ;

ROSENTHAL, D ;

SUIT, HD .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1993, 26 (03) :491-497

[8] Radiation therapy in the treatment of Gorham disease [J].

Fontanesi, J .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2003, 25 (10) :816-817

[9] DISAPPEARING BONES - A RARE FORM OF MASSIVE OSTEOLYSIS - REPORT OF 2 CASES, ONE WITH AUTOPSY FINDINGS [J].

GORHAM, LW ;

WRIGHT, AW ;

SHULTZ, HH ;

MAXON, FC .

AMERICAN JOURNAL OF MEDICINE, 1954, 17 (05) :674-682

[10] α-2b interferon and oral clodronate for Gorham's disease [J].

Hagberg, F ;

Lamberg, K ;

Åström, G .

LANCET, 1997, 350 (9094) :1822-1823

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