Synthesis of 3,5-disubstituted-1H-pyrazoles from acid chlorides, alkynes, and hydrazine in the presence of silica-supported-zinc bromide

被引：6

作者：

Keivanloo, Ali ^{[1
]}

Bakherad, Mohammad ^{[1
]}

Samangooei, Shahrzad ^{[1
]}

机构：

[1] Shahrood Univ Technol, Sch Chem, Shahrood, Iran

来源：

JOURNAL OF CHEMICAL RESEARCH | 2015年 / 08期

关键词：

palladium and copper free conditions; terminal alkynes; pyrazoles; silica supported zinc bromide; TERMINAL ALKYNES; PYRAZOLES; INHIBITORS; DERIVATIVES; KETONES; LIGAND; POTENT;

D O I：

10.3184/174751915X14382642961716

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot palladium-and copper-free procedure has been developed for a convenient synthesis of 3,5-disubstituted-1H-pyrazoles from various acid chlorides, terminal alkynes and hydrazine by a coupling reaction and cyclocondensation sequence. Acid chlorides react with terminal alkynes in the presence of silica-supported-zinc bromide to give alpha, beta-unsaturated ynones, and in situ conversion into pyrazoles by the hydrazine cyclocondensation.

引用

页码：484 / 486

页数：3

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