New Cytotoxic Metabolites from the Marine-Derived Fungus Penicillium sp ZLN29

被引：18

作者：

Gao, Huquan ^{[1
]}

Zhou, Lina ^{[1
]}

Li, Dehai ^{[1
]}

Gu, Qianqun ^{[1
]}

Zhu, Tian-Jiao ^{[1
]}

机构：

[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2013年 / 96卷 / 03期

关键词：

Penicillium sp; ZLN29; Prenpenicillide; Prenxanthone; Cytotoxic activity; Marine fungi; Polyketides; NERVE GROWTH-FACTOR; SYMPHONIA-GLOBULIFERA; ROOT BARK; POTENTIATORS; INHIBITORS; XANTHONES; NG-012; ASSAY;

D O I：

10.1002/hlca.201200596

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One new penicillide derivative, prenpenicillide (1), and one new xanthone derivative, prenxanthone (2), were isolated from the culture extract of the marine-derived fungus Penicillium sp. ZLN29, together with six known polyketide compounds, 38. Their structures were elucidated on the basis of spectroscopic and spectrometric analyses. The cytotoxicities of these eight compounds were evaluated on four tumor-cell lines by SRB (=sulforhodamine B) or MTT (=3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) methods. Compounds 1 and 3 exhibited weak cytotoxicities against HepG2 cell line with IC50 values of 9.9 and 9.7M, respectively.

引用

收藏

页码：514 / 519

页数：6

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