Contribution of Common Genetic Variants to Antidepressant Response

被引：174

作者：

Tansey, Katherine E. ^{[1
]}

Guipponi, Michel ^{[3
]}

Hu, Xiaolan ^{[6
]}

Domenici, Enrico ^{[5
,7
]}

Lewis, Glyn ^{[2
]}

Malafosse, Alain ^{[3
,4
]}

Wendland, Jens R. ^{[5
]}

Lewis, Cathryn M. ^{[1
]}

McGuffin, Peter ^{[1
]}

Uher, Rudolf ^{[1
,8
]}

机构：

[1] Kings Coll London, Inst Psychiat, London SE5 8AF, England

[2] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England

[3] Univ Hosp Geneva, Dept Genet Med & Labs, Geneva, Switzerland

[4] Univ Geneva, Dept Psychiat, CH-1211 Geneva 4, Switzerland

[5] F Hoffmann La Roche, Pharma Res & Early Dev, Basel, Switzerland

[6] Pfizer Inc, Mol Med, Groton, CT 06340 USA

[7] GlaxoSmithKline Med Res Ctr, Ctr Excellence Drug Discovery Psychiat, Verona, Italy

[8] Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada

来源：

BIOLOGICAL PSYCHIATRY | 2013年 / 73卷 / 07期

基金：

英国医学研究理事会;

关键词：

Antidepressant; GCTA; genetics; GWAS; heritability; pharmacogenomics; GENOME-WIDE ASSOCIATION; GENDEP PROJECT; PROPORTION; DEPRESSION; DISORDER; SNPS; TOOL;

D O I：

10.1016/j.biopsych.2012.10.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Pharmacogenetic studies aiming to personalize the treatment of depression are based on the assumption that response to antidepressants is a heritable trait, but there is no compelling evidence to support this. Methods: We estimate the contribution of common genetic variation to antidepressant response with Genome-Wide Complex Trait Analysis in a combined sample of 2799 antidepressant-treated subjects with major depressive disorder and genome-wide genotype data. Results: We find that common genetic variants explain 42% (SE = .180, p = .009) of individual differences in antidepressant response. Conclusions: These results suggest that response to antidepressants is a complex trait with substantial contribution from a large number of common genetic variants of small effect.

引用

页码：679 / 682

页数：4

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