In situ photo-patterning of pressure-resistant hydrogel membranes with controlled permeabilities in PEGDA microfluidic channels

被引:36
作者
Decock, Jeremy [1 ]
Schlenk, Mathias [2 ]
Salmon, Jean-Baptiste [1 ]
机构
[1] Univ Bordeaux, CNRS, Solvay, LOF,UMR 5258, F-33600 Pessac, France
[2] Univ Bayreuth, Phys Chem 1, D-95440 Bayreuth, Germany
关键词
POROUS POLYMER MONOLITHS; FABRICATION; PROTEINS; FLOW; MICROCHANNELS; PERFORMANCE; DIALYSIS; VALVES; CHIPS; FLUID;
D O I
10.1039/c7lc01342f
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
We report the fabrication of highly permeable membranes in poly.ethylene glycol) diacrylate (PEGDA) channels, for investigating ultra- or micro-filtration, at the microfluidic scale. More precisely, we used a maskless UV projection setup to photo-pattern PEG-based hydrogel membranes on a large scale (mm-cm), and with a spatial resolution of a few microns. We show that these membranes can withstand trans-membrane pressure drops of up to 7 bar without any leakage, thanks to the strong anchoring of the hydrogel to the channel walls. We also report in situ measurements of the Darcy permeability of these membranes, as a function of the deposited energy during photo-polymerization, and their formulation composition. We show that the use of PEG chains as porogens, as proposed in [Lee et al., Biomacromolecules, 2010, 11, 3316], significantly increases the porosity of the hydrogels, up to Darcy permeabilities of about 1.5 x 10(-16) m(2), while maintaining the strong mechanical stability of the membranes. We finally illustrate the opportunities offered by this technique, by investigating frontal filtration of colloidal dispersions in a straight microfluidic channel.
引用
收藏
页码:1075 / 1083
页数:9
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