共 34 条
Acinetobacter baumannii Outer Membrane Vesicles Elicit a Potent Innate Immune Response via Membrane Proteins
被引:97
作者:

Jun, So Hyun
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h-index: 0
机构:
Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea

Lee, Jung Hwa
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h-index: 0
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Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea

Kim, Bo Ra
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h-index: 0
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Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea

Kim, Seung Il
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机构:
Korea Basic Sci Inst, Div Life Sci, Taejon, South Korea Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea

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Lee, Je Chul
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h-index: 0
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Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea

Lee, Yoo Chul
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h-index: 0
机构:
Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea
机构:
[1] Kyungpook Natl Univ, Sch Med, Dept Microbiol, Taegu, South Korea
[2] Korea Basic Sci Inst, Div Life Sci, Taejon, South Korea
[3] Kyungpook Natl Univ, Sch Med, Dept Pathol, Taegu, South Korea
来源:
PLOS ONE
|
2013年
/
8卷
/
08期
关键词:
PSEUDOMONAS-AERUGINOSA;
CELL;
BIOGENESIS;
PATHOGEN;
BIOFILM;
ROLES;
D O I:
10.1371/journal.pone.0071751
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Acinetobacter baumannii is increasingly becoming a major nosocomial pathogen. This opportunistic pathogen secretes outer membrane vesicles (OMVs) that interact with host cells. The aim of this study was to investigate the ability of A. baumannii OMVs to elicit a pro-inflammatory response in vitro and the immunopathology in response to A. baumannii OMVs in vivo. OMVs derived from A. baumannii ATCC 19606(T) induced expression of pro-inflammatory cytokine genes, interleukin (IL)-beta b and IL-6, and chemokine genes, IL-8, macrophage inflammatory protein-1 alpha, and monocyte chemoattractant protein-1, in epithelial cells in a dose-dependent manner. Disintegration of OMV membrane with ethylenediaminetetraacetic acid resulted in low expression of pro-inflammatory cytokine genes, as compared with the response to intact OMVs. In addition, proteinase K-treated A. baumannii OMVs did not induce significant increase in expression of pro-inflammatory cytokine genes above the basal level, suggesting that the surface-exposed membrane proteins in intact OMVs are responsible for pro-inflammatory response. Early inflammatory processes, such as vacuolization and detachment of epithelial cells and neutrophilic infiltration, were clearly observed in lungs of mice injected with A. baumannii OMVs. Our data demonstrate that OMVs produced by A. baumannii elicit a potent innate immune response, which may contribute to immunopathology of the infected host.
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