Role of Oxidative Stress in Refractory Epilepsy: Evidence in Patients and Experimental Models

被引：106

作者：

Cardenas-Rodriguez, Noemi ^{[1
]}

Huerta-Gertrudis, Bernardino ^{[1
]}

Rivera-Espinosa, Liliana ^{[2
]}

Montesinos-Correa, Hortencia ^{[3
]}

Bandala, Cindy ^{[4
]}

Carmona-Aparicio, Liliana ^{[1
]}

Coballase-Urrutia, Elvia ^{[1
]}

机构：

[1] Natl Inst Pediat, Lab Neurochem, Mexico City 04530, DF, Mexico

[2] Natl Inst Pediat, Pharmacol Lab, Mexico City 04530, DF, Mexico

[3] Natl Inst Pediat, Dept Endocrinol, Mexico City 04530, DF, Mexico

[4] Natl Inst Rehabil, Unit Support Res, Mexico City 14389, DF, Mexico

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 01期

关键词：

oxidative stress; free radicals; refractory epilepsy; pharmacoresistant epilepsy; NITRIC-OXIDE SYNTHASES; NATURAL VITAMIN-E; SUPEROXIDE-DISMUTASE; GLUTATHIONE-PEROXIDASE; INTRACTABLE EPILEPSY; EXPERIMENTAL SEIZURES; CEREBROSPINAL-FLUID; LIPID-PEROXIDATION; STATUS EPILEPTICUS; SURGICAL-TREATMENT;

D O I：

10.3390/ijms14011455

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with refractoriness to drug therapy at about 30%. Currently, experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy. Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology.

引用

页码：1455 / 1476

页数：22

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