Relationship of negative symptom severity with cognitive symptoms and functioning in subjects at ultra-high risk for psychosis

被引：10

作者：

Ucok, Alp ^{[1
]}

Direk, Nese ^{[2
]}

Kaya, Hatice ^{[3
]}

Caglar, Nuran ^{[1
]}

Cikrikcili, Ugur ^{[4
]}

Noyan, Handan ^{[5
]}

Yokusoglu, Cagdas ^{[6
]}

Devrim-Ucok, Muge ^{[7
]}

机构：

[1] Istanbul Univ, Dept Psychiat, Istanbul Fac Med, Millet St, Istanbul, Turkey

[2] Dokuz Eylul Univ, Dept Psychiat, Fac Med, Izmir, Turkey

[3] Sultanbeyli State Hosp, Istanbul, Turkey

[4] Artvin State Hosp, Artvin, Turkey

[5] Istinye Univ, Dept Psychol, Fac Sci & Literature, Istanbul, Turkey

[6] Anamur State Hosp, Mersin, Turkey

[7] Istanbul Univ, Dept Physiol, Istanbul Fac Med, Istanbul, Turkey

来源：

EARLY INTERVENTION IN PSYCHIATRY | 2021年 / 15卷 / 04期

关键词：

cognition; functioning; negative symptoms; ultra-high risk for psychosis; CLINICAL HIGH-RISK; NEUROCOGNITIVE PERFORMANCE; REWARD ANTICIPATION; INDIVIDUALS; SCHIZOPHRENIA; DEFICITS; ASSOCIATION; PREVENTION; AVOLITION; MEDIATE;

D O I：

10.1111/eip.13042

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Aim Negative symptoms and cognition are related with functioning in schizophrenia. However, it is not clear whether they have a similar effect in individuals at ultra-high risk (UHR) for psychosis. In this study, we aimed to explore relationship of negative symptoms with cognition and functioning cross-sectionally in people with UHR for psychosis. Methods In total, 107 people participated in this study. We assessed negative symptoms with Scale for Negative Symptoms (SANS). We applied a cognitive battery including seven tests. We evaluated functioning by using Global Assessment of Functioning Scale and work/study status as an indicator of role functioning. Results SANS scores were correlated to global functioning cross-sectionally. SANS total score was correlated to cognitive test scores related to cognitive flexibility and attention. Only Trail Making Test B (TMT B) was negatively correlated to global functioning. SANS-affective blunting and SANS-avolition scores were independently related to global functioning. There was a significant indirect effect of the TMT B and composite attention scores on global functioning through negative symptoms indicating a complete mediation. Conclusion Our findings suggest that negative symptoms, particularly avolition have an impact on functioning and the association of cognition with functioning was mediated by negative symptoms in UHR.

引用

页码：966 / 974

页数：9

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