A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

被引：23

作者：

Chen, Lin ^{[1
,2
,3
]}

Shan, Lianhai ^{[1
]}

Xu, Wenliang ^{[1
]}

Zhang, Jifa ^{[1
]}

Huang, Shuai ^{[1
]}

Zhou, Xianli ^{[1
,2
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu, Peoples R China

[2] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu, Peoples R China

[3] China West Normal Univ, Sch Chem & Chem Engn, Nanchong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Diterpenoid alkaloid; pubesine; Aconitum soongaricum var. pubescens; cytotoxic activity; DITERPENOID ALKALOIDS; ROOTS;

D O I：

10.1080/14786419.2016.1198348

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new denudatine-type C-20-diterpenoid alkaloid, pubesine (1), along with seven known diterpenoid alkaloids, altaconitine (2), 14-benzoylaconine (3), spicatine A (4), 14-benzoylaconine-8-palmitate (5), 14-O-acetylsenbusine A (6), senbusine A (7) and 14-acetylneoline (8) were isolated from the whole plant of Aconitum soongaricum var. pubescens. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against H460, MCF-7 and Hep G2 human cancer cell lines.

引用

页码：523 / 528

页数：6

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