Synthesis of a new biodegradable system based on β-cyclodextrin/iron oxide nanocomposite: application for delivery of docetaxel

Magnetic nanocomposites are promising drug delivery systems for release and encapsulation of drugs because of the mild procedure of their fabrication from biopolymers, excellent chemical stability, their admissible magnetic properties and biocompatibility. The development of biocompatible carrier for hydrophobic drug delivery survives a longstanding issue in cancer therapy. We design and prepare a drug delivery system based on (beta-Cyclodextrin)-star-poly(2-hydroxyethyl methacrylate)-graft-epsilon-Caprolactone beta-CD-star-P(HEMA-g-CL) which was prepared by combining distinct polymerization techniques via ring open polymerization and reversible addition of fragmentation chain transfer polymerization. Then magnetic nanoparticles were functionalized with beta-CD-star-P(HEMA-g-CL). The morphology and nanocomposite properties behaviors were investigated by field emission scanning electron microscopy, X-ray diffraction, dynamic light scattering and vibrating sample magnetometer (VSM) analysis. The model drug applied in this study is docetaxel (DTX). DTX-encapsulation efficacy was 91.7%. Release behaviors of DTX from the magnetic nanocomposite demonstrated that the rate of DTX release could be efficiently controlled through pH.