Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium

被引：13

作者：

Auernheimer, J ^{[1
]}

Kessler, H ^{[1
]}

机构：

[1] Tech Univ Munich, Lehrstuhl Organ Chem 2, Dept Chem, D-85747 Garching, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 02期

关键词：

cell adhesion; titanium surface coating; phosphonic acids for coating titanium surfaces; multimeric phosphonic acids for coating titanium surfaces; integrin alpha v beta 3 binding to surfaces; cyclic RGD peptide; benzyl protected phosphonic acids;

D O I：

10.1016/j.bmcl.2005.10.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of biocompatible coatings is an ongoing issue. Mimicking the physiological adhesion process of ostcoblasts to the extracellular matrix improves cell adhesion of osteoblasts in vitro and results in improved and earlier osseous integration of implants in vivo. Titanium, an often used material in implant surgery, can be easily coated by peptides bearing phosphonic acid groups. We report here, the synthesis of benzyl protected phosphonic acids suitable for solid-phase peptide synthesis (SPPS), which can be easily deprotected with TFA. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：271 / 273

页数：3

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