Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions

被引：16

作者：

Turchetti, Giovanni ^{[1
]}

Garzoli, Stefania ^{[2
]}

Masci, Valentina Laghezza ^{[1
]}

Sabia, Carla ^{[3
]}

Iseppi, Ramona ^{[3
]}

Giacomello, Pierluigi ^{[2
]}

Tiezzi, Antonio ^{[1
]}

Ovidi, Elisa ^{[1
]}

机构：

[1] Tuscia Univ, Dept Innovat Biol Agrofood & Forestal Syst, I-01100 Viterbo, Italy

[2] Sapienza Univ, Dept Drug Chem & Technol, I-00185 Rome, Italy

[3] Univ Modena & Reggio Emilia, Dept Life Sci, I-41121 Modena, Italy

来源：

MOLECULES | 2020年 / 25卷 / 08期

关键词：

Anacardiaceae; pepper tree; antimicrobial; low-pressure column chromatography; plant compounds; minimum inhibitory concentration; gas chromatography-mass spectrometry; IN-VITRO ANTIBACTERIAL; CHEMICAL-COMPOSITION; ESSENTIAL OIL; ANTIOXIDANT; ANTIFUNGAL; ANTICANCER; METHANOL; CANDIDA; LEAVES; CLOVE;

D O I：

10.3390/molecules25081977

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Schinus molle (L.) is a dioecious plant of the Anacardiaceae family, originating in South America and currently widespread in many regions throughout the world. In this work leaf extracts and derived low-pressure column chromatography (LPCC) fractions of S. molle L. male and female plantswere investigated for the antimicrobial activity. Leaf extracts were tested on microbes Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Bacillus subtilis. Furthermore, the extracts showing antimicrobial activity were fractionated by LPCC and the obtained fractions tested on the same microorganism strains. Positive fractions were investigated by gas-chromatography/mass spectrometry (GC-MS) and were seen to be rich in sesquiterpenes, sesquiterpenoids and other terpens. The obtained effects highlighted the antimicrobial properties of S. molle (L.) leaf compounds and revealed their importance as a source of bioactive molecules of potential pharmaceutical interest. To our knowledge, this is the first paper reporting investigations on the chemical composition of the extracts and derived positive fractions from Schinus molle (L.) plants grown in central Italy

引用

页数：15

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