Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat

被引：414

作者：

Wang, Hongwei ^{[1
]}

Sun, Silong ^{[1
]}

Ge, Wenyang ^{[1
]}

Zhao, Lanfei ^{[1
]}

Hou, Bingqian ^{[1
]}

Wang, Kai ^{[2
]}

Lyu, Zhongfan ^{[1
]}

Chen, Liyang ^{[2
]}

Xu, Shoushen ^{[1
]}

Guo, Jun ^{[3
]}

Li, Min ^{[1
]}

Su, Peisen ^{[1
]}

Li, Xuefeng ^{[1
]}

Wang, Guiping ^{[1
]}

Bo, Cunyao ^{[1
]}

Fang, Xiaojian ^{[1
]}

Zhuang, Wenwen ^{[1
]}

Cheng, Xinxin ^{[1
]}

Wu, Jianwen ^{[1
]}

Dong, Luhao ^{[1
]}

Chen, Wuying ^{[1
]}

Li, Wen ^{[1
]}

Xiao, Guilian ^{[1
]}

Zhao, Jinxiao ^{[1
]}

Hao, Yongchao ^{[1
]}

Xu, Ying ^{[1
]}

Gao, Yu ^{[1
]}

Liu, Wenjing ^{[1
]}

Liu, Yanhe ^{[1
]}

Yin, Huayan ^{[1
]}

Li, Jiazhu ^{[4
]}

Li, Xiang ^{[1
]}

Zhao, Yan ^{[1
]}

Wang, Xiaoqian ^{[1
]}

Ni, Fei ^{[1
]}

Ma, Xin ^{[1
]}

Li, Anfei ^{[1
]}

Xu, Steven S. ^{[5
]}

Bai, Guihua ^{[6
]}

Nevo, Eviatar ^{[7
]}

Gao, Caixia ^{[8
]}

Ohm, Herbert ^{[9
]}

Kong, Lingrang ^{[1
]}

机构：

[1] Shandong Agr Univ, Coll Agron, State Key Lab Crop Biol, Tai An 271018, Shandong, Peoples R China

[2] Novogene Bioinformat Inst, Beijing 100083, Peoples R China

[3] Shandong Acad Agr Sci, Crop Res Inst, Jinan 250100, Shandong, Peoples R China

[4] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Shandong, Peoples R China

[5] ARS, USDA, Cereal Crops Res Unit, Edward T Schafer Agr Res Ctr, Fargo, ND 58102 USA

[6] ARS, USDA, Hard Winter Wheat Genet Res Unit, Manhattan, KS 66506 USA

[7] Univ Haifa, Inst Evolut, IL-3498838 Haifa, Israel

[8] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Cell & Chromosome Engn, Beijing 100101, Peoples R China

[9] Purdue Univ, Dept Agron, W Lafayette, IN 47907 USA

来源：

SCIENCE | 2020年 / 368卷 / 6493期

基金：

中国国家自然科学基金;

关键词：

THINOPYRUM-PONTICUM; GENOME SEQUENCE; EXPRESSED GENES; DEOXYNIVALENOL; PREDICTION; ALIGNMENT; IDENTIFICATION; RECONSTRUCTION; TRANSCRIPTOME; GLUTATHIONE;

D O I：

10.1126/science.aba5435

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fusarium head blight (FHB), a fungal disease caused by Fusarium species that produce food toxins, currently devastates wheat production worldwide, yet few resistance resources have been discovered in wheat germplasm. Here, we cloned the FHB resistance gene Fhb7 by assembling the genome of Thinopyrum elongatum, a species used in wheat distant hybridization breeding. Fhb7 encodes a glutathione S-transferase (GST) and confers broad resistance to Fusarium species by detoxifying trichothecenes through de-epoxidation. Fhb7 GST homologs are absent in plants, and our evidence supports that Th. elongatum has gained Fhb7 through horizontal gene transfer (HGT) from an endophytic Epichloe species. Fhb7 introgressions in wheat confers resistance to both FHB and crown rot in diverse wheat backgrounds without yield penalty, providing a solution for Fusarium resistance breeding.

引用

页码：844 / +

页数：97

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