ACUTE PAINFUL AUTOIMMUNE NEUROPATHY: A VARIANT OF GUILLAIN-BARRE SYNDROME

被引：29

作者：

Yuki, Nobuhiro ^{[1
,2
]}

Chan, Amanda C. ^{[3
]}

Wong, Anna Hiu Yi ^{[1
]}

Inoue, Takayuki ^{[1
]}

Yokai, Masafumi ^{[4
]}

Kurihara, Takashi ^{[4
]}

Devaux, Jerome J. ^{[5
]}

Wilder-Smith, Einar ^{[1
,3
,6
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore

[3] Natl Univ Hosp Syst, Dept Neurol, Singapore, Singapore

[4] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Pharmacol, Kagoshima, Japan

[5] Aix Marseille Univ, CNRS, CRN2M, UMR 7286, Marseille, France

[6] Kantonsspital Luzern, Dept Neurol, Luzern, Switzerland

来源：

MUSCLE & NERVE | 2018年 / 57卷 / 02期

基金：

英国医学研究理事会;

关键词：

acute onset; Guillain-Barre syndrome; neuropathic pain; sensory neuropathy; small-fiber neuropathy; MYOTONIC-DYSTROPHY; CANCER; RISK; VALIDITY;

D O I：

10.1002/mus.25738

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: We present a painful small-fiber neuropathy variant of Guillain-Barre syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. Methods: Two patients received intravenous immunoglobulin, one corticosteroids. Results: The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses. Discussion: Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain-Barre syndrome.

引用

页码：320 / 324

页数：5

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