Social cognition as a mediator between neurocognition and functional outcome in individuals at clinical high risk for psychosis

被引:40
作者
Barbato, Mariapaola [1 ]
Liu, Lu [1 ]
Penn, David L. [2 ]
Keefe, Richard S. E. [3 ]
Perkins, Diana O. [4 ]
Woods, Scott W. [5 ]
Addington, Jean [1 ]
机构
[1] Univ Calgary, Dept Psychiat, Hotchkiss Brain Inst, Calgary, AB T2N 4Z6, Canada
[2] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA
[3] Duke Univ, Dept Psychiat, Durham, NC 27706 USA
[4] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA
[5] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
关键词
Schizophrenia; Clinical high risk; Neurocognition; Social cognition; Functional outcome; Mediation; ULTRA-HIGH RISK; META-ANALYSIS; FACIAL AFFECT; SCHIZOPHRENIA; RECOGNITION; PERCEPTION;
D O I
10.1016/j.schres.2013.08.015
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
In schizophrenia, neurocognition, social cognition and functional outcome are all inter-related, with social cognition mediating the impact that impaired neurocognition has on functional outcome. Less clear is the nature of the relationship between neurocognition, social cognition and functional outcome in individuals at clinical high risk (CHR) for psychosis. 137 CHR participants completed a neurocognitive test battery, a battery of social cognition tasks and the Social Functioning Scale. Confirmatory factor analysis showed that all social cognition tasks were reliable and valid measures of the latent variable. The path from neurocognition to functioning was statistically significant (standardized coefficient beta = 0.22, p < 0.01). The path from social cognition to functioning was also statistically significant (beta = 0.27, p < 0.05). In the mediation model the bootstrapping estimate revealed a nonsignificant indirect effect that was the association of social cognition with neurocognition and with functional outcome (beta = 0.20, 95% CI=-0.07 to 0.52, p = 0.11). However, social cognition was significantly associated with neurocognition (beta = 0.80, p < 0.001) and the path from neurocognition to functioning was no longer significant as soon as the mediator (social cognition) was entered into the mediation model (beta = 0.02, p = 0.92). All of the model fit indices were very good. Unlike what has been observed with psychotic patients, social cognition does not seem to mediate the pathway from neurocognition to functional outcome when assessed with a measure of social attainment in individuals at CHR for psychosis. (C) 2013 Elsevier B. V. All rights reserved.
引用
收藏
页码:542 / 546
页数:5
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