Bio-ink for on-demand printing of living cells

被引：135

作者：

Ferris, Cameron J. ^{[1
,2
]}

Gilmore, Kerry J. ^{[1
]}

Beirne, Stephen ^{[1
]}

McCallum, Donald ^{[1
,2
]}

Wallace, Gordon G. ^{[1
]}

Panhuis, Marc In Het ^{[1
,2
]}

机构：

[1] Univ Wollongong, AIIM Facil, ARC Ctr Excellence Electromat Sci, Intelligent Polymer Res Inst, Wollongong, NSW 2522, Australia

[2] Univ Wollongong, Sch Chem, Soft Mat Grp, Wollongong, NSW 2522, Australia

来源：

BIOMATERIALS SCIENCE | 2013年 / 1卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

TISSUE ENGINEERING APPLICATIONS; GELLAN GUM; FLUID; MICROARRAYS; TECHNOLOGY; VIABILITY; DELIVERY;

D O I：

10.1039/c2bm00114d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Drop-on-demand bioprinting allows the controlled placement of living cells, and will benefit research in the fields of tissue engineering, drug screening and toxicology. We show that a bio-ink based on a novel microgel suspension in a surfactant-containing tissue culture medium can be used to reproducibly print several different cell types, from two different commercially available drop-on-demand printing systems, over long printing periods. The bio-ink maintains a stable cell suspension, preventing the settling and aggregation of cells that usually impedes cell printing, whilst meeting the stringent fluid property requirements needed to enable printing even from many-nozzle commercial inkjet print heads. This innovation in printing technology may pave the way for the biofabrication of multi-cellular structures and functional tissue.

引用

页码：224 / 230

页数：7

共 38 条

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