Near infrared dye loaded copper sulfide-apoferritin for tumor imaging and photothermal therapy

被引:16
作者
He, Yuanyuan [1 ]
Shen, Yuanzhi [1 ]
Zhou, Siqi [2 ]
Wu, Yihui [3 ]
Yuan, Zhenwei [1 ]
Wei, Chen [1 ]
Gui, Lijuan [1 ]
Chen, Yisha [1 ]
Gu, Yueqing [1 ]
Chen, Haiyan [1 ]
机构
[1] China Pharmaceut Univ, State Key Lab Nat Med, Sch Engn, Dept Biomed Engn, 24 Tongjia Lane, Nanjing 210009, Jiangsu, Peoples R China
[2] JSerra Catholic High Sch, 26351 Junipero Serra Rd, San Juan Capistrano, CA 92675 USA
[3] Anglo Chinese Sch Int, 61 Jln Hitam Manis, Singapore 278475, Singapore
来源
RSC ADVANCES | 2018年 / 8卷 / 26期
关键词
GUIDED PHOTOTHERMAL/PHOTODYNAMIC THERAPY; HEMORRHAGIC-FEVER ARENAVIRUSES; CANCER-THERAPY; POLYPYRROLE NANOPARTICLES; CONTRAST AGENT; GRAPHENE OXIDE; NANOCAGES; RECEPTOR; CELLS; FLUORESCENCE;
D O I
10.1039/c8ra00911b
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Development of photothermal agents for imaging-guided photothermal therapy (PTT) has been of great interest in the field of nanomedicine. CuS-apoferritin was prepared by a biomimetic synthesis method by using the inside cavity of apoferritin to control the size of CuS nanoparticles. Then, a water-soluble near infrared (NIR) dye (MBA) was bound with CuS-apoferritin, forming a nanocomplex (CuS-apoferritin-MBA) with greatly enhanced photothermal conversion efficiency compared to CuS-apoferritin. The unique optical behavior of CuS-apoferritin-MBA enables fluorescence imaging and photothermal therapy at separated optical wavelengths both, with optimized performances. CuS-apoferritin-MBA was then utilized as a photothermal agent for imaging-guided photothermal therapy in tumor-bearing mouse models. As revealed by in vivo fluorescence imaging, CuS-apoferritin-MBA showed high tumor uptake owing to an enhanced permeability and retention effect and the active targeting of apoferritin. In vivo photothermal therapy experiments indicated that tumors could be ablated by combining CuS-apoferritin-MBA with irradiation of an 808 nm laser. Thus, our work presents a safe, simple photothermal nanocomplex, promising for future clinical translation in cancer treatment.
引用
收藏
页码:14268 / 14279
页数:12
相关论文
共 36 条
[1]   Simultaneous Time-Dependent Surface-Enhanced Raman Spectroscopy, Metabolomics, and Proteomics Reveal Cancer Cell Death Mechanisms Associated with Gold Nanorod Photothermal Therapy [J].
Ali, Moustafa R. K. ;
Wu, Yue ;
Hang, Tiegang ;
Zang, Xiaoling ;
Xiao, Haopeng ;
Tang, Yan ;
Wu, Ronghu ;
Fernandez, Facundo M. ;
El-Sayed, Mostafa A. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (47) :15434-15442
[2]   Protein nanocages for self-triggered nuclear delivery of DNA-targeted chemotherapeutics in Cancer Cells [J].
Bellini, Michela ;
Mazzucchelli, Serena ;
Galbiati, Elisabetta ;
Sommaruga, Silvia ;
Fiandra, Luisa ;
Truffi, Marta ;
Rizzuto, Maria A. ;
Colombo, Miriam ;
Tortora, Paolo ;
Corsi, Fabio ;
Prosperi, Davide .
JOURNAL OF CONTROLLED RELEASE, 2014, 196 :184-196
[3]   A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway [J].
Budhathold-Uprety, Januka ;
Langenbacher, Rachel E. ;
Jena, Prakrit V. ;
Roxbury, Daniel ;
Heller, Daniel A. .
ACS NANO, 2017, 11 (04) :3875-3882
[4]   Metal-Enhanced Near-Infrared Fluorescence by Micropatterned Gold Nanocages [J].
Camposeo, Andrea ;
Persano, Luana ;
Manco, Rita ;
Wang, Yi ;
Del Carro, Pompilio ;
Zhang, Chao ;
Li, Zhi-Yuan ;
Pisignano, Dario ;
Xia, Younan .
ACS NANO, 2015, 9 (10) :10047-10054
[5]   Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging [J].
Chen, Mei ;
Chen, Shuzhen ;
He, Chengyong ;
Mo, Shiguang ;
Wang, Xiaoyong ;
Liu, Gang ;
Zheng, Nanfeng .
NANO RESEARCH, 2017, 10 (04) :1234-1248
[6]   Near-infrared dye bound albumin with separated imaging and therapy wavelength channels for imaging-guided photothermal therapy [J].
Chen, Qian ;
Wang, Chao ;
Zhan, Zhixiong ;
He, Weiwei ;
Cheng, Zhenping ;
Li, Youyong ;
Liu, Zhuang .
BIOMATERIALS, 2014, 35 (28) :8206-8214
[7]   Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses [J].
Choe, Hyeryun ;
Jemielity, Stephanie ;
Abraham, Jonathan ;
Radoshitzky, Sheli R. ;
Farzan, Michael .
CURRENT OPINION IN MICROBIOLOGY, 2011, 14 (04) :476-482
[8]   Sn Cation Valency Dependence in Cation Exchange Reactions Involving Cu2-xSe Nanocrystals [J].
De Trizio, Luca ;
Li, Hongbo ;
Casu, Alberto ;
Genovese, Alessandro ;
Sathya, Ayyappan ;
Messina, Gabriele C. ;
Manna, Liberato .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (46) :16277-16284
[9]   Ferritin binding in the developing mouse brain follows a pattern similar to myelination and is unaffected by the jimpy mutation [J].
Hulet, SW ;
Menzies, S ;
Connor, JR .
DEVELOPMENTAL NEUROSCIENCE, 2002, 24 (2-3) :208-213
[10]   Near-Infrared (NIR)-Absorbing Conjugated Polymer Dots as Highly Effective Photothermal Materials for In Vivo Cancer Therapy [J].
Li, Shengliang ;
Wang, Xiaoyu ;
Hu, Rong ;
Chen, Hui ;
Li, Meng ;
Wang, Jianwu ;
Wang, Yunxia ;
Liu, Libing ;
Lv, Fengting ;
Liang, Xing-Jie ;
Wang, Shu .
CHEMISTRY OF MATERIALS, 2016, 28 (23) :8669-8675