Use of novel oral anticoagulant agents in venous thromboembolism

被引:16
作者
Madan, Shivanshu [1 ]
Shah, Shenil [2 ]
Dale, Patrick [3 ]
Partovi, Sasan [4 ]
Parikh, Sahil A. [5 ,6 ,7 ]
机构
[1] Univ North Carolina Hosp, Dept Cardiovasc Med, Chapel Hill, NC USA
[2] Univ Wisconsin, Dept Cardiovasc Med, Madison, WI USA
[3] Univ North Carolina Hosp, Dept Internal Med, Chapel Hill, NC USA
[4] Univ Hosp Cleveland, Dept Radiol, Med Ctr, 2074 Abington Rd, Cleveland, OH 44106 USA
[5] Columbia Univ, Med Ctr, Ctr Intervent Vasc Therapy, 161 Ft Washington Ave,6th Floor, New York, NY 10032 USA
[6] Columbia Univ, Med Ctr, Div Cardiol, Dept Med, 161 Ft Washington Ave,6th Floor, New York, NY 10032 USA
[7] Columbia Univ Coll Phys & Surg, 161 Ft Washington Ave,6th Floor, New York, NY 10032 USA
关键词
Warfarin; dabigatran; apixaban; rivaroxaban; edoxaban; deep vein; thrombosis; pulmonary embolism (PE); FACTOR-XA INHIBITOR; VITAMIN-K ANTAGONIST; ATRIAL-FIBRILLATION; KNEE REPLACEMENT; DABIGATRAN ETEXILATE; COST-EFFECTIVENESS; ENOXAPARIN PLUS; IN-VITRO; RIVAROXABAN; THROMBOPROPHYLAXIS;
D O I
10.21037/cdt.2016.11.17
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
New oral anticoagulants (NOAC) serve as alternatives for patients currently using warfarin for the prevention and treatment of venous thromboembolic (VTE) disease. This article provides a brief summary of the clinical use of these drugs as well as a review of the landmark clinical trials which evaluated described their safety and efficacy. As more data becomes available, a fundamental understanding of these medications will be vital to cardiovascular practitioners managing patients with VTE.
引用
收藏
页码:570 / 581
页数:12
相关论文
共 49 条
[1]   Oral Apixaban for the Treatment of Acute Venous Thromboembolism [J].
Agnelli, Giancarlo ;
Buller, Harry R. ;
Cohen, Alexander ;
Curto, Madelyn ;
Gallus, Alexander S. ;
Johnson, Margot ;
Masiukiewicz, Urszula ;
Pak, Raphael ;
Thompson, John ;
Raskob, Gary E. ;
Weitz, Jeffrey I. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (09) :799-808
[2]   Apixaban for Extended Treatment of Venous Thromboembolism [J].
Agnelli, Giancarlo ;
Buller, Harry R. ;
Cohen, Alexander ;
Curto, Madelyn ;
Gallus, Alexander S. ;
Johnson, Margot ;
Porcari, Anthony ;
Raskob, Gary E. ;
Weitz, Jeffrey I. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (08) :699-708
[3]  
[Anonymous], 2008, CLIN PHARMACOKINET, V47, P285
[4]   Pharmacology and management of the vitamin K antagonists [J].
Ansell, Jack ;
Hirsh, Jack ;
Hylek, Elaine ;
Jacobson, Alan ;
Crowther, Mark ;
Palareti, Gualtiero .
CHEST, 2008, 133 (06) :160S-198S
[5]   Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban [J].
Ansell, Jack E. ;
Bakhru, Sasha H. ;
Laulicht, Bryan E. ;
Steiner, Solomon S. ;
Grosso, Michael ;
Brown, Karen ;
Dishy, Victor ;
Noveck, Robert J. ;
Costin, James C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (22) :2141-2142
[6]  
Bauer KA, HEMATOLOGY AM SOC HE
[7]   Oral Rivaroxaban for Symptomatic Venous Thromboembolism. [J].
Bauersachs, Rupert ;
Berkowitz, Scott D. ;
Brenner, Benjamin ;
Buller, Harry R. ;
Decousus, Herve ;
Gallus, Alex S. ;
Lensing, Anthonie W. ;
Misselwitz, Frank ;
Prins, Martin H. ;
Raskob, Gary E. ;
Segers, Annelise ;
Verhamme, Peter ;
Wells, Phil ;
Agnelli, Giancarlo ;
Bounameaux, Henri ;
Cohen, Alexander ;
Davidson, Bruce L. ;
Piovella, Franco ;
Schellong, Sebastian .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (26) :2499-2510
[8]  
Bookhart Brahim K, 2014, J Med Econ, V17, P691, DOI 10.3111/13696998.2014.946993
[9]   Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism [J].
Bueller, Harry R. ;
Decousus, Herve ;
Grosso, Michael A. ;
Mercuri, Michele ;
Middeldorp, Saskia ;
Prins, Martin H. ;
Raskob, Gary E. ;
Schellong, Sebastian M. ;
Schwocho, Lee ;
Segers, Annelise ;
Shi, Minggao ;
Verhamme, Peter ;
Wells, Phil .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (15) :1406-1415
[10]   Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary Embolism [J].
Buller, Harry R. ;
Prins, Martin H. ;
Lensing, Anthonie W. A. ;
Decousus, Herve ;
Jacobson, Barry F. ;
Minar, Erich ;
Chlumsky, Jaromir ;
Verhamme, Peter ;
Wells, Phil ;
Agnelli, Giancarlo ;
Cohen, Alexander ;
Berkowitz, Scott D. ;
Bounameaux, Henri ;
Davidson, Bruce L. ;
Misselwitz, Frank ;
Gallus, Alex S. ;
Raskob, Gary E. ;
Schellong, Sebastian ;
Segers, Annelise .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (14) :1287-1297