Design, synthesis, and biological activity of novel 4-(3,4dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives

被引：28

作者：

Liu, CL ^{[1
]}

Li, L

Li, ZM

机构：

[1] Shenyang Res Inst Chem Ind, Agrochem Discovery Dept, Shenyang 110021, Peoples R China

[2] Nankai Univ, State Key Lab Elemento Organ Chem, Inst Elemento Organ Chem, Tianjin 300071, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 11期

关键词：

thiazolecarboxylic acid derivatives; synthesis; biological activity;

D O I：

10.1016/j.bmc.2004.03.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel 4-(3,4-dimethoxyphenyl)-2-methylthiazole-5-carboxylic acid derivatives (11-23) were synthesized from 3,4-dimethoxyacetophenone (5) in six-step procedure. Their biological activities were evaluated in the greenhouse. Some of the compounds had shown fungicidal and insecticidal activities at 375 g ai/ha and 600 g ai/ha, respectively. 2004 Elsevier Ltd. All rights reserved.

引用

页码：2825 / 2830

页数：6

共 19 条

[1]

BRYANT R, 2000, AG CHEM NEW COMPOUND, P29

[2]

Jacobson R. M., 1990, US Pat., Patent No. 4970224

[3]

JACOBSON RM, 2000, Patent No. 6147062

[4] SYNTHESES AND REACTIONS OF 2-HALO-5-THIAZOLECARBOXYLATES [J].

LEE, LF ;

SCHLEPPNIK, FM ;

HOWE, RK .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1985, 22 (06) :1621-1630

[5]

Li Z., 2000, US patent, Patent No. [USP 6020,332, 6020332, US6020332]

[6]

LIU CL, 2003, Patent No. 1118465C

[7] SELF-INHIBITOR OF BEAN RUST UREDOSPORES - METHYL 3,4-DIMETHOXYCINNAMATE [J].

MACKO, V ;

STAPLES, RC ;

GERSHON, H ;

RENWICK, JAA .

SCIENCE, 1970, 170 (3957) :539-&

[8]

MORRISON GC, 1984, Patent No. 0126651

[9]

NICKL J, 1984, Patent No. 120321

[10]

Pepin R., 1994, U.S. Patent, Patent No. 5342835

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