Synthesis of optically active α-amino esters via dynamic kinetic resolution:: A mechanistic study

被引：61

作者：

Ben, RN

Durst, T ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

[2] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 21期

关键词：

D O I：

10.1021/jo9811625

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of N-protected optically active alpha-amino esters from racemic alpha-halo esters via dynamic kinetic resolution (DKR) mill be described. This methodology is general in nature and provides the desired optically active N-protected amino esters in 70-95% yield with diastereomeric excesses in the range of 85 to >98%. Applications and mechanistic aspects mill be discussed.

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页码：7700 / 7706

页数：7

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