Overcoming Nonviral Gene Delivery Barriers: Perspective and Future

被引：329

作者：

Jones, Charles H. ^{[1
]}

Chen, Chih-Kuang ^{[1
]}

Ravikrishnan, Anitha ^{[1
]}

Rane, Snehal ^{[1
]}

Pfeifer, Blaine A. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem & Biol Engn, Buffalo, NY 14260 USA

来源：

MOLECULAR PHARMACEUTICS | 2013年 / 10卷 / 11期

关键词：

gene delivery; gene therapy; nonviral vectors; lipoplexes; polyplexes; NUCLEIC-ACID DELIVERY; RING-OPENING POLYMERIZATION; MINICIRCLE DNA VECTORS; PROTEIN-KINASE-C; CATIONIC LIPIDS; IN-VIVO; SIRNA DELIVERY; PLASMID DNA; TRANSFECTION EFFICIENCY; MOLECULAR-WEIGHT;

D O I：

10.1021/mp400467x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A key end goal of gene delivery research is to develop clinically relevant vectors that can be used to combat elusive diseases such as AIDS. Despite promising engineering strategies, efficiency and ultimately gene modulation efficacy of nonviral vectors have been hindered by numerous in vitro and in vivo barriers that have resulted in subviral performance. In this perspective, we concentrate on the gene delivery barriers associated with the two most common classes of nonviral vectors, cationic-based lipids and polymers. We present the existing delivery barriers and summarize current vector-specific strategies to overcome said barriers.

引用

页码：4082 / 4098

页数：17

共 141 条

[11] A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA [J].

Brandén, LJ ;

Mohamed, AJ ;

Smith, CIE .

NATURE BIOTECHNOLOGY, 1999, 17 (08) :784-787

[12] Synthesis, activity, and structure-activity relationship studies of novel cationic lipids for DNA transfer [J].

Byk, G ;

Dubertret, C ;

Escriou, V ;

Frederic, M ;

Jaslin, G ;

Rangara, R ;

Pitard, B ;

Crouzet, J ;

Wils, P ;

Schwartz, B ;

Scherman, D .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (02) :224-235

[13] Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems [J].

Cartier, R ;

Reszka, R .

GENE THERAPY, 2002, 9 (03) :157-167

[14] Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer [J].

Chen, Chih-Kuang ;

Law, Wing-Cheung ;

Aalinkeel, Ravikumar ;

Nair, Bindukumar ;

Kopwitthaya, Atcha ;

Mahajan, Supriya D. ;

Reynolds, Jessica L. ;

Zou, Jiong ;

Schwartz, Stanley A. ;

Prasad, Paras N. ;

Cheng, Chong .

ADVANCED HEALTHCARE MATERIALS, 2012, 1 (06) :751-761

[15] Targeted Nanoparticles Deliver siRNA to Melanoma [J].

Chen, Yunching ;

Bathula, Surendar R. ;

Yang, Qi ;

Huang, Leaf .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (12) :2790-2798

[16] Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy [J].

Chen, Yunching ;

Wu, Jinzi J. ;

Huang, Leaf .

MOLECULAR THERAPY, 2010, 18 (04) :828-834

[17] Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo [J].

Chen, ZY ;

He, CY ;

Ehrhardt, A ;

Kay, MA .

MOLECULAR THERAPY, 2003, 8 (03) :495-500

[18] New cationic liposomes for gene transfer into mammalian cells with high efficiency and low toxicity [J].

Choi, JS ;

Lee, EJ ;

Jang, HS ;

Park, JS .

BIOCONJUGATE CHEMISTRY, 2001, 12 (01) :108-113

[19] Application of Living Free Radical Polymerization for Nucleic Acid Delivery [J].

Chu, David S. H. ;

Schellinger, Joan G. ;

Shi, Julie ;

Convertine, Anthony J. ;

Stayton, Patrick S. ;

Pun, Suzie H. .

ACCOUNTS OF CHEMICAL RESEARCH, 2012, 45 (07) :1089-1099

[20] Cationic liposomes for gene delivery:: From biophysics to biological applications [J].

de Lima, MCP ;

Neves, S ;

Filipe, A ;

Düzgünes, N ;

Simoes, S .

CURRENT MEDICINAL CHEMISTRY, 2003, 10 (14) :1221-1231

← 1 2 3 4 5 6 7 8 9 10 →