Overcoming Nonviral Gene Delivery Barriers: Perspective and Future

被引：324
|
作者：
Jones, Charles H. [1 ]
Chen, Chih-Kuang [1 ]
Ravikrishnan, Anitha [1 ]
Rane, Snehal [1 ]
Pfeifer, Blaine A. [1 ]
机构：
[1] SUNY Buffalo, Dept Chem & Biol Engn, Buffalo, NY 14260 USA
来源：
MOLECULAR PHARMACEUTICS | 2013年 / 10卷 / 11期
关键词：
gene delivery; gene therapy; nonviral vectors; lipoplexes; polyplexes; NUCLEIC-ACID DELIVERY; RING-OPENING POLYMERIZATION; MINICIRCLE DNA VECTORS; PROTEIN-KINASE-C; CATIONIC LIPIDS; IN-VIVO; SIRNA DELIVERY; PLASMID DNA; TRANSFECTION EFFICIENCY; MOLECULAR-WEIGHT;
D O I：
10.1021/mp400467x
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A key end goal of gene delivery research is to develop clinically relevant vectors that can be used to combat elusive diseases such as AIDS. Despite promising engineering strategies, efficiency and ultimately gene modulation efficacy of nonviral vectors have been hindered by numerous in vitro and in vivo barriers that have resulted in subviral performance. In this perspective, we concentrate on the gene delivery barriers associated with the two most common classes of nonviral vectors, cationic-based lipids and polymers. We present the existing delivery barriers and summarize current vector-specific strategies to overcome said barriers.
引用
收藏
页码：4082 / 4098
页数：17
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