Structural Studies of Conotoxins

被引：44

作者：

Daly, Norelle L. ^{[1
]}

Craik, David J.

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

来源：

IUBMB LIFE | 2009年 / 61卷 / 02期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Conus; cystine knot; disulfide isomers; NMR; toxins; NICOTINIC ACETYLCHOLINE-RECEPTORS; GATED SODIUM-CHANNELS; ALPHA-CONOTOXINS; CONUS PEPTIDES; OMEGA-CONOTOXIN; CRYSTAL-STRUCTURE; ANGSTROM RESOLUTION; HOMOLOG ACHBP; ION CHANNELS; BINDING;

D O I：

10.1002/iub.158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Conotoxins are small disulfide-rich peptides from the venoms of marine cone snails. They target a variety of ion channels, transporters, and receptors besides the interest in their natural functions in venoms and they are of much interest as drug leads. This short article gives an overview of the structural diversity of conotoxins, and illustrates this diversity with recent selected examples of conotoxin structures. (c) 2009 IUBMB

引用

页码：144 / 150

页数：7

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