PREPARATION AND CHARACTERIZATION OF NIOSOMES CONTAINING METRONIDAZOLE

被引：0

作者：

Stan, Catalina Daniela ^{[1
]}

Tataringa, Gabriela ^{[2
]}

Gafitanu, Carmen ^{[3
]}

Dragan, Maria ^{[1
]}

Braha, Steriana ^{[3
]}

Popescu, Maria Cristina ^{[5
]}

Lisa, Gabriela ^{[6
]}

Stefanache, Alina ^{[4
]}

机构：

[1] Univ Med & Pharm Gr T Popa Iasi, Fac Pharm, Dept Drug Ind & Pharmaceut Biotechnol, Iasi 700115, Romania

[2] Univ Med & Pharm Gr T Popa Iasi, Fac Pharm, Dept Organ Chem, Iasi 700115, Romania

[3] Univ Med & Pharm Gr T Popa Iasi, Fac Pharm, Dept Pharmaceut Technol, Iasi 700115, Romania

[4] Univ Med & Pharm Gr T Popa Iasi, Fac Pharm, Dept Gen & Inorgan Chem, Iasi 700115, Romania

[5] P Poni Romanian Acad, Inst Macromol Chem, Dept Phys Chem Polymers, Iasi 700487, Romania

[6] Gh Asachi Tech Univ, Fac Chem Engn & Environm Protect, Dept Phys Chem, Iasi 700050, Romania

来源：

FARMACIA | 2013年 / 61卷 / 06期

关键词：

metronidazole; niosomes; entrapment; surfactants; SURFACTANT VESICLES; LIPOSOMES; DELIVERY; CARRIERS; DRUG;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study the preparation and the characterization of non-ionic surfactant vesicles (NSV, niosomes) containing metronidazole are described. NSV were prepared by lipid film hydration technique using non-ionic surfactants with cholesterol at 1:2 and 1:1 ratio. At the same time NSV were characterized by melting points, by IR spectroscopy, by TG/DTG (thermogravimetry/derived thermogravimetry) and entrapment efficiency of metronidazole (metronidazole percent concentration). The maximum metronidazole entrapment was observed in the case of non-ionic surfactant/cholesterol use at 1:1 ratio.

引用

页码：1178 / 1185

页数：8

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