SPME-GC-MS analysis of α-pyrrolidinovaleorophenone in blood in a fatal poisoning case

被引：56

作者：

Saito, Takeshi ^{[1
]}

Namera, Akira ^{[2
]}

Osawa, Motoki ^{[3
]}

Aoki, Hiromichi ^{[1
]}

Inokuchi, Sadaki ^{[1
]}

机构：

[1] Tokai Univ, Dept Emergency & Crit Care Med, Sch Med, Isehara, Kanagawa 2591143, Japan

[2] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Forens Med, Minami Ku, Hiroshima 7348551, Japan

[3] Tokai Univ, Dept Forens Med, Sch Med, Isehara, Kanagawa 2591143, Japan

来源：

FORENSIC TOXICOLOGY | 2013年 / 31卷 / 02期

关键词：

alpha-Pyrrolidinovaleorophenone; Designer drug; Gas chromatography-mass spectrometry; Poisoning; DRUGS;

D O I：

10.1007/s11419-013-0183-8

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

We provided toxicological analytical support for a fatal case of abuse of alpha-pyrrolidinovaleorophenone (alpha-PVP). Solid-phase microextraction (SPME) and capillary gas chromatography coupled to mass spectrometry (GC-MS) was employed to quantify the drug in whole blood. The whole blood concentration of the drug in the heart was 486 ng/ml. This is the first report of alpha-PVP intoxication as ascertained by mass spectrometric identification of alpha-PVP in whole blood.

引用

页码：328 / 332

页数：5

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