Synthesis of ferrocene-functionalized monomers for biodegradable polymer formation

被引：20
作者：
Upton, Brianna M. [1 ]
Gipson, Raymond M. [1 ]
Duhovic, Selma [1 ]
Lydon, Brian R. [1 ]
Matsumoto, Nicholas M. [1 ]
Maynard, Heather D. [1 ]
Diaconescu, Paula L. [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
来源：
INORGANIC CHEMISTRY FRONTIERS | 2014年 / 1卷 / 03期
基金：
美国国家科学基金会;
关键词：
RING-OPENING POLYMERIZATION; ALIPHATIC POLYESTERS; MEDICINAL CHEMISTRY; CYCLIC CARBONATE; CLICK CHEMISTRY; ORGANOCATALYSTS; BIOMATERIALS; EXPLORATION; RESISTANT; LACTONES;
D O I：
10.1039/c3qi00041a
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Cyclic carbonate and delta-valerolactone substrates functionalized with ferrocene were synthesized via alkyne-azide "click" cycloaddition. The cyclic carbonates were polymerized using 1,8-diazabicycloundec- 7-ene, 1-(3,5-bis(trifluoromethyl) phenyl)-3-cyclohexylthiourea, and benzyl alcohol. The resulting polymers were characterized by GPC, NMR spectroscopy, and cyclic voltammetry studies. It was found that polycarbonate molecular weights fall in the range of 4.1-5.2 x 10(3) g mol(-1) with polydispersities as low as 1.26. Electrochemistry studies allowed us to identify the monomer/polymer pair with the most desirable redox potential for biological studies.
引用
收藏
页码：271 / 277
页数：7
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