Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities

被引：44

作者：

Park, Kyoung Jin ^{[1
]}

Kim, Chung Sub ^{[1
,4
,5
]}

Khan, Zahra ^{[2
,3
]}

Oh, Joonseok ^{[4
,5
]}

Kim, Sun Yeou ^{[2
,3
]}

Choi, Sang Un ^{[6
]}

Lee, Kang Ro ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 16419, South Korea

[2] Gachon Univ, Gachon Inst Pharmaceut Sci, Incheon 21936, South Korea

[3] Gachon Univ, Coll Pharm, 191 Hambakmoero, Incheon 21936, South Korea

[4] Yale Univ, Dept Chem, New Haven, CT 06520 USA

[5] Yale Univ, Chem Biol Inst, West Haven, CT 06516 USA

[6] Korea Res Inst Chem Technol, Daejeon 34114, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

GLYCOSIDES;

D O I：

10.1021/acs.jnatprod.9b00142

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new Securinega alkaloids, securingines A-G (1-7), together with seven known analogues (8-14), were isolated from the twigs of Securinega suffruticosa. Their chemical structures were elucidated by a combined approach of spectroscopic analysis, chemical methods, ECD calculations, and DP4+ probability analysis. The full NMR assignments and the absolute configuration of compound 8 are also reported. In addition, all the isolated phytochemicals (1-14) were assessed for their cytotoxic, anti-inflammatory, and potential neuroprotective activities. Compound 4 showed cytotoxic activity (IC50 values of 1.5-6.8 mu M) against four human cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15). Compounds 3, 10, 12, and 13 showed potent inhibitory effects on nitric oxide production (IC50 values of 12.6, 12.1, 1.1, and 7.7 mu M, respectively) in lipopolysaccharide-stimulated murine microglia BV-2 cells. Compound 5 exhibited a nerve growth factor production effect (172.6 +/- 1.2%) in C6 glioma cells at 20 mu g/mL.

引用

页码：1345 / 1353

页数：9

共 27 条

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