Changes in the electrical properties at an early stage of mouse liver carcinogenesis

被引：14

作者：

Bharati, Sanjay ^{[1
]}

Rishi, Praveen ^{[2
]}

Tripathi, Surya Kant ^{[3
]}

Koul, Ashwani ^{[1
]}

机构：

[1] Panjab Univ, Dept Biophys, Chandigarh 160014, India

[2] Panjab Univ, Dept Microbiol, Chandigarh 160014, India

[3] Panjab Univ, Dept Phys, Chandigarh 160014, India

来源：

BIOELECTROMAGNETICS | 2013年 / 34卷 / 06期

关键词：

hepatocellular carcinoma (HCC); scanning electron microscopy (SEM); dielectric properties; HEPATOCELLULAR-CARCINOMA; IMPEDANCE SPECTROSCOPY; DIELECTRIC-PROPERTIES; CONDUCTIVITY; TISSUE;

D O I：

10.1002/bem.21783

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The present investigation reports the changes in the electrical properties of hepatic tissue in the frequency range of 100Hz to 5MHz at an early stage of liver carcinogenesis using the four-pin electrode method. The hepatocarcinogenesis model was developed by intraperitoneal injection of N-nitrosodiethylamine (NDEA) to male Balb/c mice. Histopathological assessment revealed high-grade dysplasia in the liver of NDEA-treated animals. The ultrastructural investigations indicated the presence of large and clumped cells with inconspicuous cell boundaries. The treatment resulted in significant changes in the dielectric properties of the tissues. A decrease in tissue conductivity along with an increase in relative permittivity was observed. The biophysical changes correlated well with histoarchitectural and morphological changes. The alterations in architectural arrangement and membrane structure of cells may be responsible for the observed changes in the dielectric properties. Bioelectromagnetics. 34:429-436. (c) 2013 Wiley Periodicals, Inc.

引用

页码：429 / 436

页数：8

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