Control of voltage-dependent biomolecules via nonequilibrium kinetic focusing

We show that voltage-sensitive macromolecules can, by the application of the right type of external voltage fluctuations, be focused with great probability into a desired kinetic substate. As an illustration we consider an eight-state model of the Shaker K+ channel driven by dichotomous voltage fluctuations. This technique may provide a powerful new tool for the study of the kinetics of voltage sensitive ion channels.