Preparation and characterization of electrospun polycaprolactone/polyethylene oxide membranes

被引：17

作者：

Nien, Yu-Hsun ^{[1
]}

Shih, Chung-Yang ^{[2
]}

Yang, Chih-Yuan ^{[2
]}

Lu, Chien-Ju ^{[1
]}

Ye, Quan-Xun ^{[1
]}

机构：

[1] Natl Yunlin Univ Sci & Technol, Dept Chem & Mat Engn, Touliu, Taiwan

[2] Kun Shan Univ, Dept Polymer Mat, Yung Kang, Taiwan

来源：

JOURNAL OF POLYMER RESEARCH | 2013年 / 20卷 / 06期

关键词：

Polycaprolactone; Polyethylene oxide; Electrospinning; POLY(ETHYLENE OXIDE); RELEASE; POLY(EPSILON-CAPROLACTONE); NANOFIBERS; BLENDS; PHASE;

D O I：

10.1007/s10965-013-0166-9

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this study, we prepared electrospun polycaprolactone/polyethylene oxide (PCL/PEO) membranes fabricated by electrospinning. We designed the membranes for the application of medical patch. In order to understand the drug-released behavior when the membranes were used in medical patch, ketoprofen was used as a model drug. The results show that ketoprofen-loaded electrospun membranes that comprised PCL/PEO released all ketoprofen in 30 min. The mebranes had potential application in medical patch. In additions, the viscosity of the PCL/PEO solution increased with the proportion of PEO. The low conductivities of the all PCL/PEO solutions were caused by the lack of electric charge on both PCL and PEO molecules. A higher PEO percentage was associated with high enthalpy of fusion of the electrospun PCL/PEO membrane. The crystallinity of PEO in the PCL/PEO composite decreased as the PEO content declined.

引用

页数：6

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