Zn(pybox)-complex-catalyzed asymmetric aqueous Mukaiyama-aldol reactions

被引：43

作者：

Jankowska, J ^{[1
]}

Mlynarski, J ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 04期

关键词：

D O I：

10.1021/jo0514568

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic asymmetric aldol reactions in aqueous media have been developed using chiral zinc complex. The aldol products have been obtained in high yields, high diastereocontrol, and good level of enantioselectivity. Various aromatic and alpha,beta-unsaturated aldehydes and silyl enol ethers derived from ketones can be employed in this reaction to provide the aldol adducts in good to high yield. The elaborated catalytic system has been found as selective for aliphatic aldehydes as well.

引用

页码：1317 / 1321

页数：5

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