Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway

被引：13
|
作者：
Ren, Xianguo [1 ,2 ]
Bo, Yun [3 ]
Fan, Junting [4 ]
Chen, Maosheng [5 ]
Xu, Daliang [6 ,7 ]
Dong, Yang [6 ,7 ]
He, Haowei [8 ]
Ren, Xianzhi [7 ]
Qu, Rong [6 ,7 ]
Jin, Yulian [6 ,7 ]
Zhao, Weihong [3 ]
Xu, Changliang [1 ,7 ]
机构：
[1] Nanjing Univ, Jinling Hosp, Natl Clin Res Ctr Kidney Dis, Sch Med, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Univ, Jinling Hosp, Dept Pediat, Sch Med, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Nanjing, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China
[5] Zhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
[6] Anhui Prov Childrens Hosp, Dept Nephrol, Hefei, Peoples R China
[7] Nanjing Univ Tradit Chinese Med, Nanjing, Jiangsu, Peoples R China
[8] Nanjing Univ, Jinling Hosp, Dept Urol, Sch Med, Nanjing, Jiangsu, Peoples R China
来源：
MEDIATORS OF INFLAMMATION | 2016年 / 2016卷
基金：
中国国家自然科学基金;
关键词：
ADRIAMYCIN-INDUCED CARDIOTOXICITY; OXIDATIVE STRESS; MOUSE MODEL; KIDNEY FIBROSIS; WISTAR RATS; NEPHROTOXICITY; NEPHROPATHY; CANCER; CELLS; GLOMERULOSCLEROSIS;
D O I：
10.1155/2016/5147571
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin-( DXR-) induced renal fibrosis in mice. The mice were pretreated for 7 days with DAL followed by a single injection of DXR (10mg/kg) via the tail vein. Renal function was analyzed 5 weeks after DXR treatment. DXR caused nephrotoxicity. The symptoms of nephrotic syndrome were greatly improved after DAL treatment. The indices of renal fibrosis, the phosphorylation of Smad3, and the expression of alpha-smooth muscle actin (alpha-SMA), fibronectin, collagen III (Col III), E-cadherin, TGF-beta, and Smad7 in response to DXR were all similarly modified by DAL. The present findings suggest that DAL improved the markers for kidney damage investigated in this model of DXR-induced experimental nephrotoxicity.
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页数：10
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