Transition Metal-Free Oxidative Radical Decarboxylation/Cyclization for the Construction of 6-Alkyl/Aryl Phenanthridines

被引：74

作者：

Lu, Shichao ^{[1
,2
,3
,4
]}

Gong, Yaling ^{[3
,4
]}

Zhou, Demin ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Natl Inst Biol Sci, Beijing 102206, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[4] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 18期

关键词：

C-BOND FORMATION; ALIPHATIC CARBOXYLIC-ACIDS; ALPHA-KETO ACIDS; 6-SUBSTITUTED PHENANTHRIDINES; DECARBOXYLATIVE ALKYNYLATION; ISOCYANIDE INSERTION; EFFICIENT SYNTHESIS; DIRECT ARYLATION; CYCLIZATION; 2-ISOCYANOBIPHENYLS;

D O I：

10.1021/acs.joc.5b01518

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A radical cascade decarboxylation/cyclization of 2-isocyanobiphenyls with aliphatic carboxylic acids as well as aromatic carboxylic acids under the transition metal-free conditions was reported. This process, which included formation of two new C-C bonds and cleavage of C-COOH bonds, afforded a novel and environmentally friendly approach to producing 6-alkyl/aryl phenanthridines with moderate to good yields.

引用

收藏

页码：9336 / 9341

页数：6

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