Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group 'Molecular Diagnostics and Therapy'

被引：22

作者：

Westphalen, Benedikt C. ^{[1
]}

Bokemeyer, Carsten ^{[2
]}

Buettner, Reinhard ^{[3
,4
,5
]}

Froehling, Stefan ^{[6
,7
,8
]}

Gaidzik, Verena I. ^{[9
]}

Glimm, Hanno ^{[10
,11
,12
,13
,14
,15
,16
]}

Hacker, Ulrich T. ^{[17
]}

Heinemann, Volker ^{[1
]}

Illert, Anna L. ^{[15
,18
,19
]}

Keilholz, Ulrich ^{[20
,21
,22
,23
,24
,25
]}

Kindler, Thomas ^{[26
]}

Kirschner, Martin ^{[27
]}

Schilling, Bastian ^{[28
,29
]}

Siveke, Jens T. ^{[30
,31
]}

Schroeder, Thomas ^{[32
]}

Tischler, Verena ^{[33
]}

Wagner, Sebastian ^{[34
]}

Weichert, Wilko ^{[35
,36
]}

Zips, Daniel ^{[37
]}

Loges, Sonja ^{[2
]}

机构：

[1] Univ Hosp, LMU Munich & Comprehens Canc Ctr, Dept Internal Med 3, Munich, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Univ Comprehens Canc Ctr Hamburg, Dept Oncol, Hematol Sect Bone Marrow Transplantat & Pneumol, Hamburg, Germany

[3] Univ Hosp Cologne, Inst Pathol, Cologne, Germany

[4] Network Genom Med, Cologne, Germany

[5] Ctr Integrated Oncol Koln Bonn, Cologne, Germany

[6] Natl Ctr Tumor Dis NCT, Dept Translat Med Oncol, Heidelberg, Germany

[7] German Canc Res Ctr, Heidelberg, Germany

[8] German Canc Consortium DKTK, Heidelberg, Germany

[9] Univ Hosp Ulm, Dept Internal Med 3, Ulm, Germany

[10] Natl Ctr Tumor Dis NCT Dresden, Dept Translat Med Oncol, Dresden, Germany

[11] German Canc Res Ctr, Dresden, Germany

[12] Natl Ctr Tumour Dis NCT Dresden, Ctr Personalized Oncol, Dresden, Germany

[13] Tech Univ Dresden, Univ Hosp Carl Gustav Carus Dresden, Dresden, Germany

[14] Natl Ctr Tumor Dis NCT, Translat Funct Canc Genom, Heidelberg, Germany

[15] German Canc Res Ctr, Heidelberg, Germany

[16] German Canc Consortium DKTK, Dresden, Germany

[17] Univ Leipzig, Univ Canc Ctr Leipzig UCCL, Dept Med 1, Med Ctr, Leipzig, Germany

[18] Univ Freiburg, Fac Med, Med Ctr, Dept Internal Med 1, D-79106 Freiburg, Germany

[19] German Canc Consortium DKTK, Comprehens Canc Ctr Freiburg, Heidelberg, Germany

[20] Charite Univ Med Berlin, Charite Comprehens Canc Ctr, Charitepl 1, D-10117 Berlin, Germany

[21] Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany

[22] Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany

[23] Berlin Inst Hlth, Charitepl 1, D-10117 Berlin, Germany

[24] German Canc Consortium DKTK, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[25] German Canc Res Ctr, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[26] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Univ Canc Ctr Mainz, Mainz, Germany

[27] Rhein Westfal TH Aachen, Fac Med, Dept Hematol Oncol Hemostaseol & Stem Cell Transp, Aachen, Germany

[28] Univ Hosp Wurzburg, Comprehens Canc Ctr Mainfranken, D-97080 Wurzburg, Germany

[29] Univ Hosp Wurzburg, Dept Dermatol, D-97080 Wurzburg, Germany

[30] Univ Med Essen, West German Canc Ctr, Inst Dev Canc Therapeut, Essen, Germany

[31] DKFZ, German Canc Res Ctr, German Canc Consortium, Div Solid Tumor Translat Oncol,DKTK,Partner Site, Heidelberg, Germany

[32] Heinrich Heine Univ, Fac Med, Dept Hematol Oncol & Clin Immunol, Dusseldorf, Germany

[33] Univ Hosp Bonn, Dept Pathol, Bonn, Germany

[34] Goethe Univ, Univ Hosp, Dept Med, Univ Canc Ctr Frankfurt UCT,Hematol Oncol, Frankfurt, Germany

[35] Tech Univ Munich, Inst Pathol, D-81675 Munich, Germany

[36] German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany

[37] Comprehens Canc Ctr Tubingen Stuttgart, Tubingen, Germany

来源：

EUROPEAN JOURNAL OF CANCER | 2020年 / 135卷

关键词：

Precision medicine; Precision oncology; Molecular tumour board; Molecular diagnostics; Genomic profiling; REAL-WORLD EVIDENCE; CLINICAL-ONCOLOGY; AMERICAN-SOCIETY; VARIANTS;

D O I：

10.1016/j.ejca.2020.04.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the 'German Cancer Aid' (Deutsche Krebshilfe [DKH]) a task force 'Molecular Diagnostics and Therapy' was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

共 36 条

[1] Real-World Evidence In Support Of Precision Medicine: Clinico-Genomic Cancer Data As A Case Study [J].

Agarwala, Vineeta ;

Khozin, Sean ;

Singal, Gaurav ;

O'Connell, Claire ;

Kuk, Deborah ;

Li, Gerald ;

Gossai, Anala ;

Miller, Vincent ;

Abernethy, Amy P. .

HEALTH AFFAIRS, 2018, 37 (05) :765-772

[2] Prioritizing targets for precision cancer medicine [J].

Andre, F. ;

Mardis, E. ;

Salm, M. ;

Soria, J. -C. ;

Siu, L. L. ;

Swanton, C. .

ANNALS OF ONCOLOGY, 2014, 25 (12) :2295-2303

[3] Next-Generation Sequencing in the Clinical Setting Clarifies Patient Characteristics and Potential Actionability [J].

Bieg-Bourne, Cheyennedra C. ;

Millis, Sherri Z. ;

Piccioni, David E. ;

Fanta, Paul T. ;

Goldberg, Michael E. ;

Chmielecki, Juliann ;

Parker, Barbara A. ;

Kurzrock, Razelle .

CANCER RESEARCH, 2017, 77 (22) :6313-6320

[4]

Chakravarty Debyani, 2017, JCO Precis Oncol, V2017, DOI 10.1200/PO.17.00011

[5] Core Clinical Data Elements for Cancer Genomic Repositories: A Multi-stakeholder Consensus [J].

Conley, Robert B. ;

Dickson, Dane ;

Zenklusen, Jean Claude ;

Al Naber, Jennifer ;

Messner, Donna A. ;

Atasoy, Ajlan ;

Chaihorsky, Lena ;

Collyar, Deborah ;

Compton, Carolyn ;

Ferguson, Martin ;

Khozin, Sean ;

Klein, Roger D. ;

Kotte, Sri ;

Kurzrock, Razelle ;

Lin, C. Jimmy ;

Liu, Frank ;

Marino, Ingrid ;

McDonough, Robert ;

McNeal, Amy ;

Miller, Vincent ;

Schilsky, Richard L. ;

Wang, Lisa I. .

CELL, 2017, 171 (05) :982-986

[6] Precision medicine for cancer with next-generation functional diagnostics [J].

Friedman, Adam A. ;

Letai, Anthony ;

Fisher, David E. ;

Flaherty, Keith T. .

NATURE REVIEWS CANCER, 2015, 15 (12) :747-756

[7] Phase II randomised trial comparing docetaxel given every 3 weeks with weekly schedule as second-line therapy in patients with advanced non-small-cell lung cancer (NSCLC) [J].

Gervais, R ;

Ducolone, A ;

Breton, JL ;

Braun, D ;

Lebeau, B ;

Vaylet, F ;

Debieuvre, D ;

Pujol, JL ;

Tredaniel, J ;

Clouet, P ;

Quoix, E .

ANNALS OF ONCOLOGY, 2005, 16 (01) :90-96

[8] Oncologists' and cancer patients' views on whole-exome sequencing and incidental findings: results from the CanSeq study [J].

Gray, Stacy W. ;

Park, Elyse R. ;

Najita, Julie ;

Martins, Yolanda ;

Traeger, Lara ;

Bair, Elizabeth ;

Gagne, Joshua ;

Garber, Judy ;

Janne, Pasi A. ;

Lindeman, Neal ;

Lowenstein, Carol ;

Oliver, Nelly ;

Sholl, Lynette ;

Van Allen, Eliezer M. ;

Wagle, Nikhil ;

Wood, Sam ;

Garraway, Levi ;

Joffe, Steven .

GENETICS IN MEDICINE, 2016, 18 (10) :1011-1019

[9] Physicians' Attitudes About Multiplex Tumor Genomic Testing [J].

Gray, Stacy W. ;

Hicks-Courant, Katherine ;

Cronin, Angel ;

Rollins, Barrett J. ;

Weeks, Jane C. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (13) :1317-+

[10] Personalized medicine and education: the challenge [J].

Haiech, Jacques ;

Kilhoffer, Marie-Claude .

CROATIAN MEDICAL JOURNAL, 2012, 53 (04) :298-300

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