para-Selective Alkylation of Benzamides and Aromatic Ketones by Cooperative Nickel/Aluminum Catalysis

被引：147

作者：

Okumura, Shogo ^{[1
]}

Tang, Shuwei ^{[2
]}

Saito, Teruhiko ^{[1
]}

Semba, Kazuhiko ^{[1
]}

Sakaki, Shigeyoshi ^{[2
]}

Nakao, Yoshiaki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Mat Chem, Kyoto 6158510, Japan

[2] Kyoto Univ, Fukui Inst Fundamental Chem, Sakyo Ku, Kyoto 6068103, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 44期

关键词：

N-HETEROCYCLIC CARBENE; ORGANIC-SYNTHESIS; ARENES; FUNCTIONALIZATION; HYDROARYLATION; BOND; ARYLATION; ALKENES; OLEFINS;

D O I：

10.1021/jacs.6b08767

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a method that ensures the selective alkylation of benzamides and aromatic ketones at the para-position via cooperative nickel/aluminum catalysis. Using a bulky catalyst/cocatalyst system allows reactions between benzamides and alkenes to afford the corresponding para-alkylated products. The origin of the high para-selectivity has also been investigated by density functional theory calculations.

引用

页码：14699 / 14704

页数：6

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