Autoradiographic localization of the [3H]-(S)-zacopride labelled 5-HT3 receptor in porcine brain

被引：9

作者：

Fletcher, S ^{[1
]}

Barnes, NM ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Dept Pharmacol, Birmingham B15 2TT, W Midlands, England

来源：

NEUROSCIENCE LETTERS | 1999年 / 269卷 / 02期

基金：

英国惠康基金;

关键词：

5-HT3; receptor; H-3]-(S)-zacopride; autoradiography; porcine brain;

D O I：

10.1016/S0304-3940(99)00429-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the technique of in vitro receptor autoradiography, we have determined the distribution of the [H-3]-(S)-zacopride labelled 5-HT3 receptor in porcine brain. Highest densities of 5-HT3 receptor-associated [3H]-(S)-zacopride binding were detected in areas of porcine spinal co rd, nodose ganglion, trigeminal nerve nucleus, area postrema a nd cerebral cortex, with relatively lower levels in other brain regions (e.g. hippocampus, caudate-putamen). The distribution of [H-3]-(S)zacopride binding in porcine forebrain provides further evidence for inter-species differences with respect to the differential expression of the 5-HT3 receptor in the forebrain. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：91 / 94

页数：4

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