Development of a thermogelling ophthalmic formulation of cysteine

被引：40

作者：

Dumortier, G ^{[1
]}

El Kateb, N ^{[1
]}

Sahli, M ^{[1
]}

Kedjar, S ^{[1
]}

Boulliat, A ^{[1
]}

Chaumeil, JC ^{[1
]}

机构：

[1] Univ Paris 05, Fac Sci Pharmaceut & Biol, UPRES EA 2498, Lab Galen, F-75270 Paris 06, France

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2006年 / 32卷 / 01期

关键词：

cysteine; stability; ophthalmic; Poloxamer;

D O I：

10.1080/03639040500390934

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Preliminary studies carried out with cysteine 2% solution showed that pH adjusted to isoelectrical pH (i.e., 4.9) led to enhance stability during autoclaving and ensured no significant degradation during at least 14 days if stored at 2-8 degrees C protected from light. Optimized formulations combined either cysteine(2%)/Poloxamer407(16.5%) or cysteine(2%)/Poloxamer407(20%)/Poloxamer188(5%) and were characterized by an adequate temperature of gelification (TG) (25.9 degrees C and 26.9 degrees C, respectively), an important gel strength (5.1daN and 5.3daN, respectively) and a drastic increase in the apparent viscosity between 24 degrees C and 32 degrees C (multiplication factor of 78 and 77-fold, respectively). Cysteine addition produced only slight but significant decrease in temperature of gelification and increase in gel strength.

引用

页码：63 / 72

页数：10

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