Prions in Yeast

被引：324

作者：

Liebman, Susan W. ^{[1
]}

Chernoff, Yury O. ^{[2
]}

机构：

[1] Univ Nevada, Dept Biochem & Mol Biol, Reno, NV 89557 USA

[2] Georgia Inst Technol, Sch Biol, Atlanta, GA 30332 USA

来源：

GENETICS | 2012年 / 191卷 / 04期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

DE-NOVO APPEARANCE; BETA-SHEET STRUCTURES; RNQ1 NONPRION DOMAIN; N-TERMINAL DOMAIN; PSI+ PRION; SACCHAROMYCES-CEREVISIAE; URE3; PRION; HET-S; TRANSLATION TERMINATION; AMYLOID FIBRILS;

D O I：

10.1534/genetics.111.137760

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The concept of a prion as an infectious self-propagating protein isoform was initially proposed to explain certain mammalian diseases. It is now clear that yeast also has heritable elements transmitted via protein. Indeed, the "protein only" model of prion transmission was first proven using a yeast prion. Typically, known prions are ordered cross-beta aggregates (amyloids). Recently, there has been an explosion in the number of recognized prions in yeast. Yeast continues to lead the way in understanding cellular control of prion propagation, prion structure, mechanisms of de novo prion formation, specificity of prion transmission, and the biological roles of prions. This review summarizes what has been learned from yeast prions.

引用

页码：1041 / 1072

页数：32

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