Carrier-free, functionalized drug nanoparticles for targeted drug delivery

被引：69

作者：

Li, Wei ^{[1
,2
]}

Yang, Yinlong ^{[1
,2
]}

Wang, Chao ^{[1
,2
]}

Liu, Zhuang ^{[1
,2
]}

Zhang, Xiujuan ^{[1
,2
]}

An, Feifei ^{[3
,4
]}

Diao, Xiaojun ^{[1
,2
]}

Hao, Xiaojun ^{[1
,2
]}

Zhang, Xiaohong ^{[3
,4
]}

机构：

[1] Soochow Univ, Funct Nano & Soft Mat Lab FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

[3] Chinese Acad Sci, Tech Inst Phys & Chem, Nanoorgan Photoelect Lab, Beijing 100190, Peoples R China

[4] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 65期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

VASCULAR-PERMEABILITY; THERAPY;

D O I：

10.1039/c2cc33214k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate a new concept of carrier-free functionalized drug nanoparticles for targeted drug delivery. It exhibits significantly enhanced drug efficacy to folate receptor-positive cells with high selectivity and a high drug loading content up to more than 78%.

引用

页码：8120 / 8122

页数：3

共 20 条

[1] Nanomaterials: Applications in Cancer Imaging and Therapy [J].

Barreto, Jose A. ;

O'Malley, William ;

Kubeil, Manja ;

Graham, Bim ;

Stephan, Holger ;

Spiccia, Leone .

ADVANCED MATERIALS, 2011, 23 (12) :H18-H40

[2] Nanoparticles for Drug Delivery Prepared from Amphiphilic PLGA Zwitterionic Block Copolymers with Sharp Contrast in Polarity between Two Blocks [J].

Cao, Zhiqiang ;

Yu, Qiuming ;

Xue, Hong ;

Cheng, Gang ;

Jiang, Shaoyi .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (22) :3771-3776

[3] Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device [J].

Dhar, Shanta ;

Liu, Zhuang ;

Thomale, Juergen ;

Dai, Hongjie ;

Lippard, Stephen J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (34) :11467-11476

[4] Nanocrystal technology, drug delivery and clinical applications [J].

Junghanns, Jens-Uwe A. H. ;

Mueller, Rainer H. .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2008, 3 (03) :295-309

[5] Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives [J].

Knop, Katrin ;

Hoogenboom, Richard ;

Fischer, Dagmar ;

Schubert, Ulrich S. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (36) :6288-6308

[6]

Lipinski C., AM PHARM REV, V5, P82

[7] Drug-like properties and the causes of poor solubility and poor permeability [J].

Lipinski, CA .

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2000, 44 (01) :235-249

[8] Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review [J].

Maeda, H ;

Wu, J ;

Sawa, T ;

Matsumura, Y ;

Hori, K .

JOURNAL OF CONTROLLED RELEASE, 2000, 65 (1-2) :271-284

[9] Formulation and antitumor activity evaluation of nanocrystalline suspensions of poorly soluble anticancer drugs [J].

MeriskoLiversidge, E ;

Sarpotdar, P ;

Bruno, J ;

Hajj, S ;

Wei, L ;

Peltier, N ;

Rake, J ;

Shaw, JM ;

Pugh, S ;

Polin, L ;

Jones, J ;

Corbett, T ;

Cooper, E ;

Liversidge, GG .

PHARMACEUTICAL RESEARCH, 1996, 13 (02) :272-278

[10] Nanocarriers as an emerging platform for cancer therapy [J].

Peer, Dan ;

Karp, Jeffrey M. ;

Hong, SeungPyo ;

FaroKHzad, Omid C. ;

Margalit, Rimona ;

Langer, Robert .

NATURE NANOTECHNOLOGY, 2007, 2 (12) :751-760

← 1 2 →