Determination of critical eluent composition for polyethylenglycols using on-line liquid chromatography -: Fourier transform infrared spectrometry

被引:17
作者
Kuligowski, J. [1 ]
Quintas, G. [1 ]
Garrigues, S. [1 ]
de la Guardia, M. [1 ]
机构
[1] Univ Valencia, Dept Analyt Chem, E-46100 Burjassot, Spain
关键词
liquid chromatography; fourier transform infrared spectrometry; on-line background correction; gradient elution;
D O I
10.1016/j.aca.2008.06.055
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In this work, it has been extended to methanol:water mobile phases, the use of a background correction method for on-line LC-FTIR measurements named Univariate background correction based on the use of a reference spectra Matrix (UBC-RSM) and absorbance ratios. It permits to overcome the problem related to spectral changes occurring during the gradient elution, which in the past limited the on-line coupling of LC and FTIR to isocratic elutions. The combined use of the aforementioned background correction technique in on-line isocratic and gradient LC-FTIR, and partial least squares (PLS) has been applied for the search of the critical conditions for polymers. Polyethylen glycol (PEG) has been used as a model example and results found fitted well with previously published ones. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:278 / 285
页数:8
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