Age-related changes in detection of spatial novelty

被引：4
作者：
Maasberg, David W. [2 ]
Shelley, Laura E. [2 ]
Gilbert, Paul E. [1 ,2 ]
机构：
[1] SDSU UCSD Joint Doctoral Program Clin Psychol, San Diego, CA 92120 USA
[2] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA
来源：
BEHAVIOURAL BRAIN RESEARCH | 2012年 / 228卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Aging; Spatial; Object; Novelty detection; Exploration; SHORT-TERM-MEMORY; OBJECT EXPLORATION; HIPPOCAMPAL-FORMATION; RECOGNITION MEMORY; LOCOMOTOR-ACTIVITY; RHESUS-MONKEY; WATER MAZE; OLD RATS; DEFICITS; DAMAGE;
D O I：
10.1016/j.bbr.2011.12.024
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Age-related changes in novelty detection for object-place associations was assessed in 6-mo and 25-mo-old Fisher 344/Brown Norway (F344/BN) rats. Old rats showed significant deficits compared to young rats in detecting spatial displacement of objects. The data suggest that object-place novelty detection is impaired in aged F344/BN rats using a rapidly acquired, exploratory-based task. The results may have important implications for the selection of efficient memory paradigms for future aging studies. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：447 / 451
页数：5
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