Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones

被引：46
作者：
Jiang, Chunhui
Zhong, Fangrui
Lu, Yixin [1 ]
机构：
[1] Natl Univ Singapore, Dept Chem, Inst Life Sci, Singapore 117543, Singapore
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 8卷
关键词：
decarboxylative addition; beta-keto acid; Mannich reaction; organocatalysis; ALPHA-IMINO ESTERS; HALF-THIOESTERS; POLYKETIDE BIOSYNTHESIS; ENANTIOSELECTIVE ADDITION; 1,3-AMINO ALCOHOLS; ZIRCONIUM CATALYST; ENAMINE CATALYSIS; MICHAEL-ADDITION; ALDOL REACTIONS; MALONIC-ACIDS;
D O I：
10.3762/bjoc.8.144
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first decarboxylative Mannich reaction employing beta-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired beta-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities.
引用
收藏
页码：1279 / 1283
页数：5
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